Emilie Logie

TL;DR: Preclinical in vivo evidence for therapeutic cancer applications of Withaferin A (WA) is summarized and a biochemical framework of its polypharmaceutical effects against cancer hallmarks is provided.

TL;DR: Among the various purified phytochemicals curcumin, germacrone, curdione, zederone, and curcumenol significantly inhibited NF-κB activation in tumor necrosis factor (TNF) stimulated HaCaT keratinocytes and was the most potent anti-inflammatory.

TL;DR: A concise overview of the molecular mechanisms by which Withaferin A orchestrates its anti-inflammatory effects to restore immune homeostasis is provided.

TL;DR: It is demonstrated that plasma treated water-derived oxidants sensitize pancreatic cancer cells to ferroptotic cell death by targeting a NRF2-HMOX1-GPX4 specific kinase signaling network.

TL;DR: It is demonstrated that mangiferin interferes with inflammation, lipid and calcium signaling which selectively inhibits multiple NFkB target genes including interleukin-6, tumor necrosis factor, interferon gamma, vascular endothelial growth factor receptor 2, plasminogen activator urokinase, matrix metalloprotease 19, C-C Motif Chemokine Ligand 2 and placental growth factor.