R
René Delgado-Hernández
Researcher at University of Havana
Publications - 27
Citations - 335
René Delgado-Hernández is an academic researcher from University of Havana. The author has contributed to research in topics: Neuroprotection & Oxidative stress. The author has an hindex of 9, co-authored 25 publications receiving 264 citations. Previous affiliations of René Delgado-Hernández include Université de Sherbrooke.
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Journal ArticleDOI
The paradox of natural products as pharmaceuticals: Experimental evidences of a mango stem bark extract
Alberto J. Núñez-Sellés,René Delgado-Hernández,Gabino Garrido-Garrido,Dagmar García-Rivera,Mariela Guevara-García,Gilberto L. Pardo-Andreu +5 more
TL;DR: Ethnomedical studies, extract reproducibility, biological effects and clinical evaluations in terms of patient quality of life are described as experimental evidences to support the statement that natural products, even being a mixture of compounds, could be as effective as "monoceuticals" for medical uses.
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A novel multi-target ligand (JM-20) protects mitochondrial integrity, inhibits brain excitatory amino acid release and reduces cerebral ischemia injury in vitro and in vivo
Yanier Nuñez-Figueredo,Jeney Ramírez-Sánchez,Gisele Hansel,Elisa Nicoloso Simões Pires,Nelson Merino,Odalys Valdés,René Delgado-Hernández,Alicia Lagarto Parra,Estael Ochoa-Rodríguez,Yamila Verdecia-Reyes,Christianne Gazzana Salbego,Silvia Lima Costa,Diogo O. Souza,Gilberto L. Pardo-Andreu +13 more
TL;DR: The results suggest that in rats, JM-20 is a robust neuroprotective agent against ischemia/reperfusion injury with a wide therapeutic window and support the further examination of potential clinicalJM-20 use to treat acute ischemic stroke.
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Antioxidant effects of JM-20 on rat brain mitochondria and synaptosomes: mitoprotection against Ca²⁺-induced mitochondrial impairment.
Yanier Nuñez-Figueredo,Gilberto L. Pardo-Andreu,Jeney Ramírez-Sánchez,René Delgado-Hernández,Estael Ochoa-Rodríguez,Yamila Verdecia-Reyes,Zeki Naal,Alexandre Pastoris Müller,Luis Valmor Cruz Portela,Diogo O. Souza +9 more
TL;DR: The antioxidant and protective effects of JM-20 against the deleterious effects of Ca(2+) observed at the mitochondrial level in this study may endow this molecule with the ability to succeed in mitochondrion-targeted strategies to combat ischemic brain damage.
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JM-20, a novel benzodiazepine–dihydropyridine hybrid molecule, protects mitochondria and prevents ischemic insult-mediated neural cell death in vitro.
Yanier Nuñez-Figueredo,Jeney Ramírez-Sánchez,René Delgado-Hernández,Marlene Porto-Verdecia,Estael Ochoa-Rodríguez,Yamila Verdecia-Reyes,Javier Marín-Prida,Michael González-Durruthy,Sérgio Akira Uyemura,Fernando P. Rodrigues,Carlos Curti,Diogo O. Souza,Gilberto L. Pardo-Andreu +12 more
TL;DR: In rat liver mitochondria, JM-20, at low micromolar concentrations, prevented the Ca2+-induced mitochondrial permeability transition, as assessed by mitochondrial swelling, membrane potential dissipation and organelle release of the pro-apoptotic protein cytochrome c.
Journal ArticleDOI
Anti-hypernociceptive effect of mangiferin in persistent and neuropathic pain models in rats
Bárbara B. Garrido-Suárez,Gabino Garrido,Marian Castro-Labrada,Nelson Merino,Odalys Valdés,Idania Rodeiro,Ivonnes Hernández,Jozi Godoy-Figueiredo,Sérgio H. Ferreira,René Delgado-Hernández +9 more
TL;DR: It is suggested that MG shows ability to decrease tonic pain in the formalin test and its neuroprotective effect by preventing WD in mononeuropathic rats could be implicated in the mechano-antihypernociceptive long term mechanisms.