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Emma M. Creagh
Researcher at Trinity College, Dublin
Publications - 43
Citations - 4936
Emma M. Creagh is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Caspase & Apoptosis. The author has an hindex of 21, co-authored 39 publications receiving 4540 citations. Previous affiliations of Emma M. Creagh include University College Cork.
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Journal ArticleDOI
TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity.
TL;DR: It is hypothesize that during the first phase of the host response to infection, an important interplay occurs between these families, providing a substantial combinatorial repertoire in innate immunity.
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Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation
James Harris,Michelle L Hartman,Caitrionna Jane Roche,Shijuan Grace Zeng,Amy O'Shea,Fiona A. Sharp,Eimear M Lambe,Emma M. Creagh,Douglas T. Golenbock,Jürg Tschopp,Hardy Kornfeld,Katherine A. Fitzgerald,Ed C. Lavelle +12 more
TL;DR: It is demonstrated that autophagy controls the production of IL-1β through at least two separate mechanisms: by targeting pro-IL-1 β for lysosomal degradation and by regulating activation of the NLRP3 inflammasome.
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Uptake of particulate vaccine adjuvants by dendritic cells activates the NALP3 inflammasome
Fiona A. Sharp,Darren Ruane,Benjamin Claass,Emma M. Creagh,James Harris,Padma Malyala,Manomohan Singh,Derek T. O'Hagan,Virginie Pétrilli,Jürg Tschopp,Luke A. J. O'Neill,Ed C. Lavelle +11 more
TL;DR: It is demonstrated that uptake of microparticulate adjuvants by DCs activates the NALP3 inflammasome, and this contributes to their enhancing effects on innate and antigen-specific cellular immunity.
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Apoptosis‐associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl‐2
TL;DR: It is reported that Smac/DIABLO export from mitochondria into the cytosol is provoked by cytotoxic drugs and DNA damage, as well as by ligation of the CD95 death receptor.
Journal ArticleDOI
Caspase‐activation pathways in apoptosis and immunity
TL;DR: The current understanding of how caspases are activated during apoptosis and inflammation and the roles these proteases play in either context are discussed.