L
Luke A. J. O'Neill
Researcher at Trinity College, Dublin
Publications - 503
Citations - 76369
Luke A. J. O'Neill is an academic researcher from Trinity College, Dublin. The author has contributed to research in topics: Innate immune system & Signal transduction. The author has an hindex of 127, co-authored 482 publications receiving 63765 citations. Previous affiliations of Luke A. J. O'Neill include Dublin Institute of Technology & Queen Elizabeth College, Mauritius.
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Journal ArticleDOI
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Gillian M. Tannahill,Anne M. Curtis,Juraj Adamik,Eva M. Palsson-McDermott,Anne F. McGettrick,Gautam Goel,Christian Frezza,Nicholas J. Bernard,Beth Kelly,Niamh Foley,Liang Zheng,A. Gardet,Zhen Tong,S. S. Jany,Sinéad C. Corr,Moritz Haneklaus,Brian E. Caffrey,Kerry A. Pierce,Sarah R. Walmsley,F. C. Beasley,Eoin P. Cummins,Victor Nizet,Moira K. B. Whyte,Cormac T. Taylor,Hening Lin,Seth L. Masters,Eyal Gottlieb,Vincent P. Kelly,Clary B. Clish,Philip E. Auron,Ramnik J. Xavier,Ramnik J. Xavier,Luke A. J. O'Neill +32 more
TL;DR: The authors showed that inhibition of glycolysis with 2-deoxyglucose suppresses lipopolysaccharide-induced interleukin-1β but not tumour-necrosis factor-α in mouse macrophages.
Journal ArticleDOI
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
TL;DR: The function of the fifth adaptor, SARM, has been revealed, which negatively regulates TRIF, and it is shown that it acts as a bridging adaptor in the initiation of TLR signalling.
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A guide to immunometabolism for immunologists
TL;DR: A brief refresher course on six of the major metabolic pathways involved in immunometabolism is provided, giving specific examples of how precise changes in the metabolites of these pathways shape the immune cell response.
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A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases
Rebecca C. Coll,Avril A. B. Robertson,Jae Jin Chae,Sarah C. Higgins,Raúl Muñoz-Planillo,Marco Inserra,Irina Vetter,Lara S. Dungan,Brian G. Monks,Andrea Stutz,Daniel E. Croker,Mark S. Butler,Moritz Haneklaus,Caroline E. Sutton,Gabriel Núñez,Eicke Latz,Daniel L. Kastner,Kingston H. G. Mills,Seth L. Masters,Kate Schroder,Mark E. Cooper,Luke A. J. O'Neill +21 more
TL;DR: MCC950 treatment rescued neonatal lethality in a mouse model of CAPS and was active in ex vivo samples from individuals with Muckle–Wells syndrome, and is a potential therapeutic for NLRP3-associated syndromes, and a tool for further study of theNLRP3 inflammasome in human health and disease.
Journal ArticleDOI
Trained immunity: A program of innate immune memory in health and disease
Mihai G. Netea,Leo A. B. Joosten,Eicke Latz,Kingston H. G. Mills,Gioacchino Natoli,Hendrik G. Stunnenberg,Luke A. J. O'Neill,Ramnik J. Xavier +7 more
TL;DR: Proof-of-principle experimental studies support the hypothesis that trained immunity is one of the main immunological processes that mediate the nonspecific protective effects against infections induced by vaccines, such as bacillus Calmette-Guérin or measles vaccination.