E
Emmanuel Bourinet
Researcher at University of Montpellier
Publications - 103
Citations - 8295
Emmanuel Bourinet is an academic researcher from University of Montpellier. The author has contributed to research in topics: Voltage-dependent calcium channel & T-type calcium channel. The author has an hindex of 46, co-authored 95 publications receiving 7504 citations. Previous affiliations of Emmanuel Bourinet include University of British Columbia & Centre national de la recherche scientifique.
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Journal ArticleDOI
Crosstalk between G proteins and protein kinase C mediated by the calcium channel α 1 subunit
TL;DR: Crosstalk results from the PKC-dependent phosphorylation of one of the Gβλ binding sites which antagonizes G βλ-induced inhibition, providing a mechanism for the highly regulated and dynamic control of neurotransmitter release that depends on the integration of multiple presynaptic signals.
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Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activity.
Matteo E. Mangoni,Brigitte Couette,Emmanuel Bourinet,Josef Platzer,Daniel Reimer,Jörg Striessnig,Joël Nargeot +6 more
TL;DR: Genetic evidence is provided linking the activity of genes coding for ionic channels to specific alterations of pacemaker activity of SAN cells to demonstrate that Cav1.3 channels play a major role in the generation of cardiacpacemaker activity by contributing to diastolic depolarization in SAN pacemaker cells.
Journal ArticleDOI
Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception
Emmanuel Bourinet,Abdelkrim Alloui,Arnaud Monteil,Christian Barrère,Brigitte Couette,Olivier Poirot,Anne Pages,John E. McRory,Terrance P. Snutch,Alain Eschalier,Joël Nargeot +10 more
TL;DR: The results provide direct evidence linking CaV3.2 T‐type channels to pain perception and suggest that CaV 3.2 may offer a specific molecular target for the treatment of pain.
Journal ArticleDOI
Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels.
Emmanuel Bourinet,Tuck Wah Soong,Tuck Wah Soong,Kathy G. Sutton,Sarah J. Slaymaker,Eleanor A. Mathews,Arnaud Monteil,Gerald W. Zamponi,Joël Nargeot,Terry P. Snutch +9 more
TL;DR: It is reported that alternative splicing of the α1A subunit gene results in channels with distinct kinetic, pharmacological and modulatory properties, as well as multiple phenotypic variants.
Journal ArticleDOI
Localization and functional properties of a rat brain alpha 1A calcium channel reflect similarities to neuronal Q- and P-type channels.
Anthony Stea,W J Tomlinson,Tuck Wah Soong,Emmanuel Bourinet,Stefan J. Dubel,Steven R. Vincent,Terry P. Snutch +6 more
TL;DR: Overall, the results show that alpha 1A channels are widely expressed and share some properties with both Q- and P-type channels.