J
Joël Nargeot
Researcher at University of Montpellier
Publications - 152
Citations - 10542
Joël Nargeot is an academic researcher from University of Montpellier. The author has contributed to research in topics: Voltage-dependent calcium channel & T-type calcium channel. The author has an hindex of 54, co-authored 147 publications receiving 9837 citations. Previous affiliations of Joël Nargeot include University of Nice Sophia Antipolis & French Institute of Health and Medical Research.
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Journal ArticleDOI
Genesis and Regulation of the Heart Automaticity
Matteo E. Mangoni,Joël Nargeot +1 more
TL;DR: Evidence on the functional role of different families of ion channels in cardiac pacemaking is discussed and recent results obtained on genetically engineered mouse strains displaying dysfunction in heart automaticity are reviewed.
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Crosstalk between G proteins and protein kinase C mediated by the calcium channel α 1 subunit
TL;DR: Crosstalk results from the PKC-dependent phosphorylation of one of the Gβλ binding sites which antagonizes G βλ-induced inhibition, providing a mechanism for the highly regulated and dynamic control of neurotransmitter release that depends on the integration of multiple presynaptic signals.
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Functional role of L-type Cav1.3 Ca2+ channels in cardiac pacemaker activity.
Matteo E. Mangoni,Brigitte Couette,Emmanuel Bourinet,Josef Platzer,Daniel Reimer,Jörg Striessnig,Joël Nargeot +6 more
TL;DR: Genetic evidence is provided linking the activity of genes coding for ionic channels to specific alterations of pacemaker activity of SAN cells to demonstrate that Cav1.3 channels play a major role in the generation of cardiacpacemaker activity by contributing to diastolic depolarization in SAN pacemaker cells.
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Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception
Emmanuel Bourinet,Abdelkrim Alloui,Arnaud Monteil,Christian Barrère,Brigitte Couette,Olivier Poirot,Anne Pages,John E. McRory,Terrance P. Snutch,Alain Eschalier,Joël Nargeot +10 more
TL;DR: The results provide direct evidence linking CaV3.2 T‐type channels to pain perception and suggest that CaV 3.2 may offer a specific molecular target for the treatment of pain.
Journal ArticleDOI
Splicing of alpha 1A subunit gene generates phenotypic variants of P- and Q-type calcium channels.
Emmanuel Bourinet,Tuck Wah Soong,Tuck Wah Soong,Kathy G. Sutton,Sarah J. Slaymaker,Eleanor A. Mathews,Arnaud Monteil,Gerald W. Zamponi,Joël Nargeot,Terry P. Snutch +9 more
TL;DR: It is reported that alternative splicing of the α1A subunit gene results in channels with distinct kinetic, pharmacological and modulatory properties, as well as multiple phenotypic variants.