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Abdelkrim Alloui
Researcher at French Institute of Health and Medical Research
Publications - 55
Citations - 5053
Abdelkrim Alloui is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Neuropathic pain & Hyperalgesia. The author has an hindex of 36, co-authored 55 publications receiving 4606 citations. Previous affiliations of Abdelkrim Alloui include University of Auvergne.
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Journal ArticleDOI
The effects of total sleep deprivation, selective sleep interruption and sleep recovery on pain tolerance thresholds in healthy subjects.
TL;DR: The analgesic effect of SWS recovery is apparently greater than the analgesia induced by level I (World Health Organization) analgesic compounds in mechanical pain experiments in healthy volunteers.
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Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception
Emmanuel Bourinet,Abdelkrim Alloui,Arnaud Monteil,Christian Barrère,Brigitte Couette,Olivier Poirot,Anne Pages,John E. McRory,Terrance P. Snutch,Alain Eschalier,Joël Nargeot +10 more
TL;DR: The results provide direct evidence linking CaV3.2 T‐type channels to pain perception and suggest that CaV 3.2 may offer a specific molecular target for the treatment of pain.
Journal ArticleDOI
TREK-1, a K+ channel involved in polymodal pain perception
Abdelkrim Alloui,Katharina Zimmermann,Julien Mamet,Fabrice Duprat,Jacques Noël,Jean Chemin,Nicolas Guy,Nicolas Blondeau,Nicolas Voilley,Catherine Rubat-Coudert,Marc Borsotto,Georges Romey,Catherine Heurteaux,Peter W. Reeh,Alain Eschalier,Michel Lazdunski +15 more
TL;DR: It is demonstrated that TREK‐1 qualifies as one of the molecular sensors involved in pain perception and as an attractive target for the development of new analgesics.
Journal ArticleDOI
ASIC3, a sensor of acidic and primary inflammatory pain
Emmanuel Deval,Jacques Noël,Nadège Lay,Abdelkrim Alloui,Sylvie Diochot,Valérie Friend,Martine Jodar,Michel Lazdunski,Eric Lingueglia +8 more
TL;DR: It is shown that ∼60% of rat cutaneous sensory neurons express ASIC3‐like currents, and peripheral ASIC3 channels are essential sensors of acidic pain and integrators of molecular signals produced during inflammation where they contribute to primary hyperalgesia.
Journal ArticleDOI
Black mamba venom peptides target acid-sensing ion channels to abolish pain
Sylvie Diochot,Anne Baron,Anne Baron,Miguel Salinas,Miguel Salinas,Dominique Douguet,Dominique Douguet,Sabine Scarzello,Sabine Scarzello,Sabine Scarzello,Anne Sophie Dabert-Gay,Anne Sophie Dabert-Gay,Delphine Debayle,Delphine Debayle,Valérie Friend,Valérie Friend,Abdelkrim Alloui,Abdelkrim Alloui,Michel Lazdunski,Michel Lazdunski,Eric Lingueglia,Eric Lingueglia +21 more
TL;DR: It is shown that a new class of three-finger peptides from another snake, the black mamba, is able to abolish pain through inhibition of ASICs expressed either in central or peripheral neurons, and these peptides are called mambalgins.