E
Eonyoung Park
Researcher at Seoul National University
Publications - 11
Citations - 672
Eonyoung Park is an academic researcher from Seoul National University. The author has contributed to research in topics: RNA splicing & Exon. The author has an hindex of 10, co-authored 11 publications receiving 587 citations. Previous affiliations of Eonyoung Park include University of Rochester.
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Journal ArticleDOI
Staufen‐mediated mRNA decay
Eonyoung Park,Lynne E. Maquat +1 more
TL;DR: Staufen1 (STAU1)‐mediated mRNA decay (SMD) is an mRNA degradation process in mammalian cells that is mediated by the binding of STAU1 to a ST AU1‐binding site within the 3′‐untranslated region of target mRNAs.
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Dual modification of BMAL1 by SUMO2/3 and ubiquitin promotes circadian activation of the CLOCK/BMAL1 complex.
Jiwon Lee,Yool Lee,Min Joo Lee,Eonyoung Park,Sung Hwan Kang,Chin Ha Chung,Kun Ho Lee,Kyungjin Kim +7 more
TL;DR: It is shown that modification by SUMO localizes BMAL1 exclusively to the promyelocytic leukemia nuclear body (NB) and simultaneously promotes its transactivation and ubiquitin-dependent degradation.
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Differential adaptive responses to chronic stress of maternally stressed male mice offspring.
TL;DR: Exposure to maternal stress in the womb can affect an animal's coping capacity to chronic postnatal stress, and it was demonstrated that a dysfunction in negative feedback inhibition of the HPA axis could be deteriorated by chronic stress in maternally stressed male mice.
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Staufen2 functions in Staufen1-mediated mRNA decay by binding to itself and its paralog and promoting UPF1 helicase but not ATPase activity
TL;DR: It is proposed that STAU paralogs contribute to SMD by “greasing the wheels” of RNA-bound UPF1 so as to enhance its unwinding capacity per molecule of ATP hydrolyzed.
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A splice variant of human Bmal1 acts as a negative regulator of the molecular circadian clock.
TL;DR: An alternative form of a key ‘clock’ protein involved in the maintenance of daily cellular rhythms serves as a negative regulator of the cell’s 24-hour cycle and drugs targeting BMAL1a may aid in sleep disorders and other circadian-linked health problems.