E
Eric Alani
Researcher at Cornell University
Publications - 103
Citations - 9029
Eric Alani is an academic researcher from Cornell University. The author has contributed to research in topics: DNA mismatch repair & DNA repair. The author has an hindex of 50, co-authored 102 publications receiving 8569 citations. Previous affiliations of Eric Alani include Massachusetts Institute of Technology & Harvard University.
Papers
More filters
Journal ArticleDOI
A method for gene disruption that allows repeated use of URA3 selection in the construction of multiply disrupted yeast strains.
TL;DR: An important feature of this 3.8-kb molecular construct that makes it especially useful is that recombination between the flanking direct repeats occurs at a high frequency (10-4) in vegetatively grown cultures.
Journal ArticleDOI
A pathway for generation and processing of double-strand breaks during meiotic recombination in S. cerevisiae
TL;DR: In this article, the authors identify and analyze a meiotic reciprocal recombination hot spot in S. cerevisiae and find that double-strand breaks occur at two specific sites associated with the hot spot and that occurrence of these breaks depends upon meiotic recombination functions RAD50 and SPO11.
Journal ArticleDOI
Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination
TL;DR: The meiotic and mitotic defects of rad50 mutants can be accounted for economically by the proposal that meiotic recombination, meiotic chromosome pairing, and vegetative DNA repair all use a common chromosomal homology search that involves RAD50 function.
Journal ArticleDOI
Distinctly regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of S. cerevisiae
TL;DR: Several experiments indicate that UAS1 and UAS2 are regulated distinctly at the molecular level, and HAP1 appears to encode a protein that mediates catabolite repression of UAS 1 by responding to intracellular heme levels.
Journal ArticleDOI
MLH1, PMS1, and MSH2 interactions during the initiation of DNA mismatch repair in yeast
TL;DR: Experiments revealed that the yeast MLH 1 and PMS1 proteins physically associate, possibly forming a heterodimer, and that MLH1 andPMS1 act in concert to bind a MSH2-heteroduplex complex containing a G-T mismatch.