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Eric Fluhler
Researcher at Pfizer
Publications - 21
Citations - 660
Eric Fluhler is an academic researcher from Pfizer. The author has contributed to research in topics: Bioanalysis & Pharmacokinetics. The author has an hindex of 13, co-authored 21 publications receiving 598 citations.
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Journal ArticleDOI
Interspecies Prediction of Human Drug Clearance Based on Scaling Data from One or Two Animal Species
TL;DR: The results showed that the rat, dog, monkey, rat-dog, and rat-monkey methods provided improved predictions for the majority of the compounds compared with those for the ROE, suggesting that the use of three or more species in an allometrically based approach may not be necessary for the prediction of human exposure.
Journal ArticleDOI
Workshop Report: Crystal City V—Quantitative Bioanalytical Method Validation and Implementation: The 2013 Revised FDA Guidance
Brian Booth,Mark E. Arnold,Binodh DeSilva,Lakshmi Amaravadi,Sherri Dudal,Eric Fluhler,Boris Gorovits,Sam H. Haidar,John Kadavil,Steve Lowes,Robert Nicholson,Marie Rock,Michael Skelly,Lauren Stevenson,Sriram Subramaniam,Russell Weiner,Eric Woolf +16 more
TL;DR: A workshop to provide a forum for an open, inclusive discussion of the revised draft BMV Guidance, the AAPS and FDA once again collaborated to convene a two-and-a-half day workshop during early December 2013, concluding with a review of the outcomes and recommendations from the thematic sessions.
Journal ArticleDOI
2013 White Paper on recent issues in bioanalysis: ‘hybrid’ – the best of LBA and LCMS
Lauren Stevenson,Fabio Garofolo,Binodh DeSilva,Isabelle Dumont,Suzanne Martinez,Mario Rocci,Lakshmi Amaravadi,Margarete Brudny-Kloeppel,Adrien Musuku,Brian Booth,Catherine Dicaire,Laura Wright,Laurence Mayrand-Provencher,Mike Losauro,Dominique Gouty,Mark E. Arnold,Surendra Bansal,Sherri Dudal,Dawn Dufield,Jeff Duggan,Christopher P. Evans,Eric Fluhler,Stephanie Fraser,Boris Gorovits,Sam Haidar,Roger Hayes,Stacy Ho,Richard Houghton,Rafiq Islam,Rand Jenkins,Noriko Katori,Surinder Kaur,Marian Kelley,Magnus Knutsson,Jean W. Lee,Hanlan Liu,Steve Lowes,Mark Ma,Alvydas Mikulskis,Heather Myler,Bob Nicholson,Timothy V Olah,Eric Ormsby,Shefali Patel,Vincenzo Pucci,Chad Ray,Gary Schultz,Judy Shih,Ronald Shoup,Craig Simon,An Song,João Tavares Neto,Valerie Theobald,Theingi M. Thway,Jason Wakelin-Smith,Jian Wang,Laixin Wang,Jan Welink,Emma Whale,Eric Woolf,Raymond Naxing Xu +60 more
TL;DR: This 2013 White Paper addresses important bioAnalytical issues and provides practical answers to the topics presented, discussed and agreed upon by the global bioanalytical community attending the 7th Workshop on Recent Issues in Bioanalysis.
Journal ArticleDOI
A sensitive human bone assay for quantitation of tigecycline using LC/MS/MS.
Allena J. Ji,James P. Saunders,Peter Amorusi,Nandan D. Wadgaonkar,Kenneth O’Leary,Mauricio Leal,Gary Dukart,Bonnie Marshall,Eric Fluhler +8 more
TL;DR: A new and sensitive human bone assay for the quantitation of tigecycline using LC/MS/MS has been developed and validated and has significantly higher extraction efficiency than the previously reported method.
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2014 White Paper on recent issues in bioanalysis: a full immersion in bioanalysis (Part 2 – hybrid LBA/LCMS, ELN & regulatory agencies’ input)
Dawn Dufield,Hendrik Neubert,Fabio Garofolo,Leo Kirkovsky,Lauren Stevenson,Isabelle Dumont,Surinder Kaur,Keyang Xu,Stephen C. Alley,Matthew Szapacs,Mark E. Arnold,Surendra Bansal,Sam Haidar,Jan Welink,Olivier Le Blaye,Jason Wakelin-Smith,Emma Whale,Akiko Ishii-Watabe,Mark Bustard,Noriko Katori,Lakshmi Amaravadi,Anne-Françoise Aubry,Chris Beaver,Annik Bergeron,Xiao-Yan Cai,Laura Cojocaru,Binodh DeSilva,Jeff Duggan,Eric Fluhler,Boris Gorovits,Swati Gupta,Roger Hayes,Stacy Ho,Benno Ingelse,Lindsay King,Ann Levesque,Steve Lowes,Mark Ma,Adrien Musuku,Heather Myler,Timothy V Olah,Shefali Patel,Mark J. Rose,Gary Schultz,John Smeraglia,Steven J. Swanson,Albert Torri,Faye Vazvaei,Amanda Wilson,Eric Woolf,Li Xue,Tong-Yuan Yang +51 more
TL;DR: The 2014 8th Workshop on Recent Issues in Bioanalysis (8th WRIB), a 5-day full immersion in the evolving field of bioanalysis, took place in Universal City, California, USA, and specific recommendations are presented in this 2014 White Paper.