Eric Maynard Davis

TL;DR: It is demonstrated that BAY 43-9006 mediates cell death in human leukemia cells, at least in part, through down-regulation of Mcl-1 via inhibition of translation.

TL;DR: It is reported that inducible expression of constitutively active MEK1 fails to protect cells from sorafenib-mediated lethality, indicating that sorafanib-induced cell death is unrelated to MEK 1/2-ERK1/2 pathway inactivation.

TL;DR: It is shown that inducible expression of constitutively active MEK1 fails to protect U937 human leukemia cells from sorafenib-mediated lethality, indicating that sorafanib-induced cell death is unrelated to MEK 1/2/ERK1/2 pathway inactivation.

TL;DR: While non-European AML patients are less likely to receive 8/8 URDs as expected, if they do their transplants are delayed, HLA-identical siblings and cord blood facilitate the fastest transplants regardless of patient ancestry whereas other adult donor transplants is delayed.