E
Eric R. Olson
Publications - 2
Citations - 521
Eric R. Olson is an academic researcher. The author has contributed to research in topics: Epigenome & Cancer. The author has an hindex of 2, co-authored 2 publications receiving 389 citations.
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Quantitative ChIP-Seq normalization reveals global modulation of the epigenome.
David A. Orlando,Mei Wei Chen,Victoria Brown,Snehakumari Solanki,Yoon Jung Choi,Eric R. Olson,Christian C. Fritz,James E. Bradner,Matthew G. Guenther +8 more
TL;DR: The utility of this method for measuring epigenomic changes following chemical perturbations is demonstrated and it is shown how reference normalization of ChIP-seq experiments enables the discovery of disease-relevant changes in histone modification occupancy.
Journal ArticleDOI
Discovery and Characterization of SY-1365, a Selective, Covalent Inhibitor of CDK7
Shanhu Hu,Jason J. Marineau,Nisha Rajagopal,Kristin B. Hamman,Yoon Jong Choi,Darby Schmidt,Nan Ke,Liv Johannessen,Michael J. Bradley,David A. Orlando,Sydney Alnemy,Yixuan Ren,Stephane Ciblat,Dana K. Winter,Anzhelika Kabro,Kevin Sprott,J. Graeme Hodgson,Christian Fritz,John Carulli,Emmanuelle di Tomaso,Eric R. Olson +20 more
TL;DR: In vitro, SY-1365 inhibited cell growth of many different cancer types at nanomolar concentrations, and anti-tumor activity was also observed in xenograft models of ovarian cancer, suggesting the potential for exploring SY- 1365 in the clinic in both hematological and solid tumors.