D
David A. Orlando
Researcher at Massachusetts Institute of Technology
Publications - 46
Citations - 14690
David A. Orlando is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Transcription factor & Enhancer. The author has an hindex of 25, co-authored 45 publications receiving 12897 citations. Previous affiliations of David A. Orlando include University of California, Berkeley & Duke University.
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Journal ArticleDOI
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
Warren A. Whyte,David A. Orlando,Denes Hnisz,Brian J. Abraham,Charles Y. Lin,Charles Y. Lin,Michael H. Kagey,Peter B. Rahl,Tong Ihn Lee,Richard A. Young +9 more
TL;DR: In this article, the ESC master transcription factors form unusual enhancer domains at most genes that control the pluripotent state, called super-enhancers, which consist of clusters of enhancers that are densely occupied by the master regulators and Mediator.
Journal ArticleDOI
Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
Jakob Lovén,Heather A. Hoke,Charles Y. Lin,Charles Y. Lin,Ashley Lau,David A. Orlando,Christopher R. Vakoc,James E. Bradner,Tong Ihn Lee,Richard A. Young +9 more
TL;DR: This work investigates how inhibition of the widely expressed transcriptional coactivator BRD4 leads to selective inhibition ofThe MYC oncogene in multiple myeloma (MM), and finds that super-enhancers were found at key oncogenic drivers in many other tumor cells.
Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes
Warren A. Whyte,David A. Orlando,Denes Hnisz,Brian J. Abraham,Charles Y. Lin,Charles Y. Lin,Michael H. Kagey,Peter B. Rahl,Tong Ihn Lee,Richard A. Young +9 more
TL;DR: It is reported here that the ESC master transcription factors form unusual enhancer domains at most genes that control the pluripotent state, which consist of clusters of enhancers that are densely occupied by the master regulators and Mediator.
Mediator and cohesin connect gene expression and chromatin architecture
Michael H. Kagey,Jamie J. Newman,Steve Bilodeau,Ye Zhan,David A. Orlando,Nynke L. van Berkum,Christopher C. Ebmeier,Jesse Goossens,Peter B. Rahl,Stuart S. Levine,Dylan J. Taatjes,Job Dekker,Richard A. Young +12 more
TL;DR: It is reported that mediator and cohesin physically and functionally connect the enhancers and core promoters of active genes in murine embryonic stem cells.
Journal ArticleDOI
A High-Resolution Root Spatiotemporal Map Reveals Dominant Expression Patterns
Siobhan M. Brady,David A. Orlando,Ji-Young Lee,Jean Y. J. Wang,Jeremy D. Koch,José R. Dinneny,Daniel L. Mace,Uwe Ohler,Philip N. Benfey +8 more
TL;DR: Methods that combine microarray expression profiles of a high-resolution set of developmental time points within a single Arabidopsis root and a comprehensive map of nearly all root cell types demonstrate transcriptionally rich and complex programs that define Arabidrosis root development in both space and time.