E
Eric Yu
Researcher at Montreal Neurological Institute and Hospital
Publications - 53
Citations - 286
Eric Yu is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Medicine & Disease. The author has an hindex of 6, co-authored 33 publications receiving 91 citations. Previous affiliations of Eric Yu include McGill University & University of Paris.
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Journal ArticleDOI
Analysis of Heterozygous PRKN Variants and Copy-Number Variations in Parkinson's Disease.
Eric Yu,Eric Yu,Uladzislau Rudakou,Uladzislau Rudakou,Lynne Krohn,Lynne Krohn,Kheireddin Mufti,Kheireddin Mufti,Jennifer A. Ruskey,Jennifer A. Ruskey,Farnaz Asayesh,Farnaz Asayesh,Mehrdad Asghari Estiar,Mehrdad Asghari Estiar,Dan Spiegelman,Dan Spiegelman,Matthew Surface,Stanley Fahn,Cheryl Waters,Lior Greenbaum,Lior Greenbaum,Alberto J. Espay,Yves Dauvilliers,Nicolas Dupré,Guy A. Rouleau,Guy A. Rouleau,Sharon Hassin-Baer,Sharon Hassin-Baer,Edward A. Fon,Edward A. Fon,Roy N. Alcalay,Ziv Gan-Or,Ziv Gan-Or +32 more
TL;DR: Biallelic PRKN mutation carriers with Parkinson's disease (PD) typically have an earlier disease onset, slow disease progression, and, often, different neuropathology compared to sporadic PD patients.
Journal ArticleDOI
Targeted sequencing of Parkinson's disease loci genes highlights SYT11, FGF20 and other associations.
Uladzislau Rudakou,Uladzislau Rudakou,Eric Yu,Eric Yu,Lynne Krohn,Lynne Krohn,Jennifer A. Ruskey,Jennifer A. Ruskey,Farnaz Asayesh,Farnaz Asayesh,Yves Dauvilliers,Dan Spiegelman,Dan Spiegelman,Lior Greenbaum,Lior Greenbaum,Stanley Fahn,Cheryl Waters,Nicolas Dupré,Guy A. Rouleau,Guy A. Rouleau,Sharon Hassin-Baer,Sharon Hassin-Baer,Edward A. Fon,Edward A. Fon,Roy N. Alcalay,Ziv Gan-Or,Ziv Gan-Or +26 more
TL;DR: In this article, the role of rare and common genetic variants within these loci was examined using optimized sequence kernel association tests, and a burden of rare variants in SYT11, FGF20 and GCH1 associated with Parkinson's disease was identified.
Posted ContentDOI
Targeted sequencing of Parkinson’s disease loci genes highlights SYT11, FGF20 and other associations
Uladzislau Rudakou,Uladzislau Rudakou,Eric Yu,Eric Yu,Lynne Krohn,Lynne Krohn,Jennifer A. Ruskey,Jennifer A. Ruskey,Farnaz Asayesh,Farnaz Asayesh,Yves Dauvilliers,Dan Spiegelman,Dan Spiegelman,Lior Greenbaum,Lior Greenbaum,Stanley Fahn,Cheryl Waters,Nicolas Dupré,Guy A. Rouleau,Guy A. Rouleau,Sharon Hassin-Baer,Sharon Hassin-Baer,Edward A. Fon,Edward A. Fon,Roy N. Alcalay,Ziv Gan-Or,Ziv Gan-Or +26 more
TL;DR: The results further demonstrate the importance of fine mapping of GWAS loci, and suggest that SYT11, FGF20, and potentially PM20D1, BST1 and GPNMB should be considered for future studies as possible Parkinson's disease-related genes.
Journal ArticleDOI
Fine mapping of the HLA locus in Parkinson's disease in Europeans.
Eric Yu,Eric Yu,Aditya Ambati,Maren Stolp Andersen,Maren Stolp Andersen,Lynne Krohn,Lynne Krohn,Mehrdad Asghari Estiar,Mehrdad Asghari Estiar,Prabhjyot Saini,Prabhjyot Saini,Konstantin Senkevich,Konstantin Senkevich,Yuri L. Sosero,Yuri L. Sosero,Ashwin Ashok Kumar Sreelatha,Jennifer A. Ruskey,Jennifer A. Ruskey,Farnaz Asayesh,Farnaz Asayesh,Dan Spiegelman,Dan Spiegelman,Mathias Toft,Mathias Toft,Marte K. Viken,Manu Sharma,Cornelis Blauwendraat,Lasse Pihlstrøm,Emmanuel Mignot,Ziv Gan-Or,Ziv Gan-Or +30 more
TL;DR: In this paper, the leukocyte antigen (HLA) region in 13,770 Parkinson's disease patients, 20,214 proxy-cases, and 490,861 controls of European origin was fine mapped.
Posted ContentDOI
Fine mapping of the HLA locus in Parkinson’s disease in Europeans
Eric Yu,Eric Yu,Aditya Ambati,Maren Stolp Andersen,Maren Stolp Andersen,Lynne Krohn,Lynne Krohn,Mehrdad Asghari Estiar,Mehrdad Asghari Estiar,Prabhjyot Saini,Prabhjyot Saini,Konstantin Senkevich,Konstantin Senkevich,Yuri L. Sosero,Yuri L. Sosero,Ashwin Ashok Kumar Sreelatha,Jennifer A. Ruskey,Jennifer A. Ruskey,Farnaz Asayesh,Farnaz Asayesh,Dan Spiegelman,Dan Spiegelman,Mathias Toft,Mathias Toft,Marte K. Viken,Manu Sharma,Cornelis Blauwendraat,Lasse Pihlstrøm,Emmanuel Mignot,Ziv Gan-Or,Ziv Gan-Or +30 more
TL;DR: The results suggest that specific variants in the HLA-DRB1 gene are associated with reduced risk of PD, providing additional evidence for the role of the immune system in PD.