E
Erich Roth
Researcher at Medical University of Vienna
Publications - 177
Citations - 8277
Erich Roth is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Glutamine & Amino acid. The author has an hindex of 49, co-authored 177 publications receiving 7880 citations. Previous affiliations of Erich Roth include University of Texas Medical Branch & University of Hohenheim.
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Journal ArticleDOI
Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns.
Kambis Sadeghi,Barbara Wessner,Ute Laggner,Martin Ploder,Dietmar Tamandl,Josef Friedl,Ullrich Zügel,Andreas Steinmeyer,Arnold Pollak,Erich Roth,George Boltz-Nitulescu,Andreas Spittler +11 more
TL;DR: The data provide strong evidence that 1,25(OH)2D3 primes monocytes to respond less effectively to bacterial cell wall components in a VDR‐dependent mechanism, most likely due to decreased levels of TLR2 and TLR4.
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Mechanism of Amino Acid-Induced Skeletal Muscle Insulin Resistance in Humans
Michael Krebs,Martin Krššák,Elisabeth Bernroider,Christian Anderwald,Attila Brehm,Martin Meyerspeer,Peter Nowotny,Erich Roth,Werner Waldhäusl,Michael Roden +9 more
TL;DR: Effects of short-term plasma amino acid elevation induces skeletal muscle insulin resistance in humans by inhibition of glucose transport/phosphorylation, resulting in marked reduction of glycogen synthesis.
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Overactivation of S6 Kinase 1 as a Cause of Human Insulin Resistance During Increased Amino Acid Availability
Frédéric Tremblay,Michael Krebs,Luce Dombrowski,Attila Brehm,Elisabeth Bernroider,Erich Roth,Peter Nowotny,Werner Waldhäusl,André Marette,Michael Roden +9 more
TL;DR: It is suggested that overactivation of the mammalian target of rapamycin/S6 kinase 1 pathway and inhibitory serine phosphorylation of insulin receptor substrate-1 underlie the impairment of insulin action in amino acid-infused humans.
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Metabolic disorders in severe abdominal sepsis: glutamine deficiency in skeletal muscle.
TL;DR: In severe sepsis metabolic changes correlate with the outcome of the patients, and amino acid metabolism seems to be characterised by low concentrations of muscle glutamine and high levels of the branched chain amino acids possibly indicating an inhibited intracellular glutamine formation in muscle tissue.
Journal ArticleDOI
l-Arginine Treatment Alters the Kinetics of Nitric Oxide and Superoxide Release and Reduces Ischemia/Reperfusion Injury in Skeletal Muscle
Igor Huk,Joseph Nanobashvili,Christoph Neumayer,Andreas Punz,Markus Mueller,Kaweh Afkhampour,Martina Mittlboeck,Udo Losert,Peter Polterauer,Erich Roth,Stephen Patton,Tadeusz Malinski +11 more
TL;DR: L-Arginine treatment decreased superoxide generation by cNOS while increasing NO accumulation, leading to protection from constriction, and reduction of edema after reperfusion in animals treated with L-arginine.