Michael Krebs

TL;DR: It is shown that S6K1 directly phosphorylates IRS-1 Ser-1101 in vitro in the C-terminal domain of the protein and that mutation of this site largely blocks the ability of amino acids to suppress IRS- 1 tyrosine and Akt phosphorylation.

TL;DR: Effects of short-term plasma amino acid elevation induces skeletal muscle insulin resistance in humans by inhibition of glucose transport/phosphorylation, resulting in marked reduction of glycogen synthesis.

TL;DR: It is suggested that overactivation of the mammalian target of rapamycin/S6 kinase 1 pathway and inhibitory serine phosphorylation of insulin receptor substrate-1 underlie the impairment of insulin action in amino acid-infused humans.

TL;DR: A consensus meeting was held in Vienna on September 8-9, 2013, to discuss diagnostic and therapeutic challenges surrounding development of diabetes mellitus after transplantation as mentioned in this paper, where 24 transplant nephrologists, surgeons, diabetologists and clinical scientists met with the aim to review previous guidelines in light of emerging clinical data and research.

TL;DR: A high incidence of Barrett’s esophagus and hiatal hernias is shown at more than 10 years after Laparoscopic sleeve gastrectomy, suggesting maintaining pre-existing large hiatAL hernia, GERD, and Barrett's esophageal reflux as relative contraindications to SG.