M
Martin Ploder
Researcher at Medical University of Vienna
Publications - 16
Citations - 991
Martin Ploder is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Neopterin & Kynurenine pathway. The author has an hindex of 11, co-authored 15 publications receiving 893 citations.
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Journal ArticleDOI
Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns.
Kambis Sadeghi,Barbara Wessner,Ute Laggner,Martin Ploder,Dietmar Tamandl,Josef Friedl,Ullrich Zügel,Andreas Steinmeyer,Arnold Pollak,Erich Roth,George Boltz-Nitulescu,Andreas Spittler +11 more
TL;DR: The data provide strong evidence that 1,25(OH)2D3 primes monocytes to respond less effectively to bacterial cell wall components in a VDR‐dependent mechanism, most likely due to decreased levels of TLR2 and TLR4.
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Modulation of toll-like receptor 4 expression on human monocytes by tumor necrosis factor and interleukin-6: tumor necrosis factor evokes lipopolysaccharide hyporesponsiveness, whereas interleukin-6 enhances lipopolysaccharide activity.
Dietmar Tamandl,Minu Bahrami,Barbara Wessner,Günter Weigel,Martin Ploder,Walter Fürst,Erich Roth,Georg Boltz-Nitulescu,Andreas Spittler +8 more
TL;DR: It is concluded that not only LPS but also TNF-&agr; and IL-6 have the potency to regulate the immune response via TLR-4 and can increase the responsiveness of mononuclear phagocytes.
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Serum phenylalanine in patients post trauma and with sepsis correlate to neopterin concentrations
Martin Ploder,Gabriele Neurauter,Andreas Spittler,Katharina Schroecksnadel,Erich Roth,Dietmar Fuchs +5 more
TL;DR: This assumption that Oxidative stress due to immune activation and inflammation may destroy cofactor 5,6,7,8-tetrahydrobiopterin and impair PAH activity is supported by the correlation found between higher neopterin concentrations and higher phenylalanine to tyrosine ratio, which estimates efficacy of PAH.
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Elevated serum levels of epithelial cell apoptosis-specific cytokeratin 18 neoepitope m30 in critically ill patients.
Georg A. Roth,Claus G. Krenn,Markus Brunner,Bernhard Moser,Martin Ploder,Andreas Spittler,Linda E. Pelinka,Thomas Sautner,Ernst Wolner,George Boltz-Nitulescu,Hendrik Jan Ankersmit +10 more
TL;DR: The increased serum level of the CK18 neoepitope in septic patients indicates a heightened apoptotic turnover in epithelial cells as compared with trauma patients and healthy controls and interestingly, nonsurviving trauma patients exhibited a significant increase in the M30 neoantigen.
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Serum concentrations of insulin-like growth factor-1, members of the TGF-beta superfamily and follistatin do not reflect different stages of dynapenia and sarcopenia in elderly women.
Marlene Hofmann,Barbara Halper,Stefan Oesen,Bernhard Franzke,Petra Stuparits,Harald Tschan,Norbert Bachl,Eva-Maria Strasser,Michael Quittan,Martin Ploder,Karl-Heinz Wagner,Barbara Wessner +11 more
TL;DR: Neither a single nor a combined set of tested biomarkers reflected the presence of dynapenia or sarcopenia in elderly women, however, due to the associations of IGF-1 and GDF-15 with correlates of muscle mass and function, these parameters remain promising candidates in a potential set of blood-based biomarkers to diagnose sarc Openia and/or dynapENia.