E
Erik Fransen
Researcher at University of Antwerp
Publications - 274
Citations - 9239
Erik Fransen is an academic researcher from University of Antwerp. The author has contributed to research in topics: Population & Single-nucleotide polymorphism. The author has an hindex of 52, co-authored 248 publications receiving 7847 citations.
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Journal ArticleDOI
Comparative analysis of dynamic cell viability, migration and invasion assessments by novel real-time technology and classic endpoint assays.
Ridha Limame,An Wouters,Bea Pauwels,Erik Fransen,Marc Peeters,Filip Lardon,Olivier De Wever,Patrick Pauwels +7 more
TL;DR: The xCELLigence RTCA technology provides an accurate platform for non-invasive detection of cell viability and motility and indicates performance characteristics and correlating dynamic observations of cell proliferation, cytotoxicity, migration and invasion on cancer cells in highly standardized experimental conditions.
Journal ArticleDOI
L1 Knockout Mice Show Dilated Ventricles, Vermis Hypoplasia and Impaired Exploration Patterns
Erik Fransen,Rudi D'Hooge,Guy Van Camp,Marleen Verhoye,Jan Sijbers,Edwin Reyniers,Philippe Soriano,Hiroyuki Kamiguchi,Rob Willemsen,Sebastiaan K. E. Koekkoek,Chris I. De Zeeuw,Peter Paul De Deyn,Annemie Van der Linden,Vance Lemmon,R. Frank Kooy,Patrick Willems +15 more
TL;DR: This work has performed further studies of these knockout mice including magnetic resonance imaging of the brain, neuropathological analysis and behavioral testing, and found the ventricular system was shown to be abnormal with dilatation of the lateral ventricles and the 4th ventricle, and an altered shape of the Sylvius aqueduct.
Journal ArticleDOI
Occupational noise, smoking, and a high body mass index are risk factors for age-related hearing impairment and moderate alcohol consumption is protective: a European population-based multicenter study.
Erik Fransen,Vedat Topsakal,Jan Hendrickx,Lut Van Laer,Jeroen R. Huyghe,Els Van Eyken,Nele Lemkens,Samuli Hannula,Elina Mäki-Torkko,Mona Jensen,Kelly Demeester,Anke Tropitzsch,Amanda Bonaconsa,Manuela Mazzoli,Angeles Espeso,Katia Verbruggen,Joke Huyghe,Patrick L. M. Huygen,Sylvia J. W. Kunst,Minna Manninen,Amalia Diaz-Lacava,Michael Steffens,Thomas F. Wienker,Ilmari Pyykkö,Cor W. R. J. Cremers,Hannie Kremer,Ingeborg Dhooge,Dafydd Stephens,Eva Orzan,Markus Pfister,Michael Bille,Agnete Parving,Martti Sorri,Paul Van de Heyning,Guy Van Camp +34 more
TL;DR: The results suggest that a healthy lifestyle can protect against age-related hearing impairment and smoking significantly increased high-frequency hearing loss, and the effect was dose-dependent.
Journal ArticleDOI
CRASH syndrome: clinical spectrum of corpus callosum hypoplasia, retardation, adducted thumbs, spastic paraparesis and hydrocephalus due to mutations in one single gene, L1.
TL;DR: The evidence that several X-linked mental retardation syndromes including HSAS, MASA, SP1 and ACC are all due to mutations in the L1 gene is reviewed, and this clinical syndrome is referred to with the acronym CRASH, for Corpus callosum hypoplasia, Retardation, Adducted thumbs, Spastic paraplegia and Hydrocephalus.
Journal ArticleDOI
GRM7 variants confer susceptibility to age-related hearing impairment
Rick A. Friedman,Lut Van Laer,Matthew J. Huentelman,Sonal S. Sheth,Els Van Eyken,Jason J. Corneveaux,Waibhav Tembe,Rebecca F. Halperin,Ashley Q. Thorburn,Sofie Thys,Sarah Bonneux,Erik Fransen,Jeroen R. Huyghe,Ilmari Pyykkö,Cor W. R. J. Cremers,Hannie Kremer,Ingeborg Dhooge,Dafydd Stephens,Eva Orzan,Markus Pfister,Michael Bille,Agnete Parving,Martti Sorri,Paul Van de Heyning,Linna Makmura,Jeffrey D. Ohmen,Fred H. Linthicum,Jose N. Fayad,John V. Pearson,David Craig,Dietrich A. Stephan,Guy Van Camp +31 more
TL;DR: Results of the first whole genome association study for ARHI indicate that common alleles of GRM7 contribute to an individual's risk of developing ARHI, possibly through a mechanism of altered susceptibility to glutamate excitotoxicity.