E
Eva Orzan
Researcher at University of Trieste
Publications - 71
Citations - 2251
Eva Orzan is an academic researcher from University of Trieste. The author has contributed to research in topics: Hearing loss & Medicine. The author has an hindex of 18, co-authored 64 publications receiving 2034 citations. Previous affiliations of Eva Orzan include University of Padua & IRCCS Materno Infantile Burlo Garofolo.
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Journal ArticleDOI
GJB2 mutations and degree of hearing loss: a multicenter study.
Rikkert L. Snoeckx,Patrick L. M. Huygen,Delphine Feldmann,Sandrine Marlin,Françoise Denoyelle,Jaroslaw Waligora,Małgorzata Mueller-Malesińska,Agneszka Pollak,Rafał Płoski,Alessandra Murgia,Eva Orzan,Pierangela Castorina,Umberto Ambrosetti,Ewa Nowakowska-Szyrwinska,Jerzy Bal,Wojciech Wiszniewski,Andreas R. Janecke,Doris Nekahm-Heis,Pavel Seeman,O. Bendová,Margaret A. Kenna,Anna Frangulov,Heidi L. Rehm,Mustafa Tekin,Armagan Incesulu,Hans Henrik M. Dahl,Desirée du Sart,Lucy Jenkins,Deirdre Lucas,Maria Bitner-Glindzicz,Karen B. Avraham,Zippora Brownstein,Ignacio del Castillo,Felipe Moreno,Nikolaus Blin,Markus Pfister,István Sziklai,Tímea Tóth,Philip M. Kelley,Edward S. Cohn,Lionel Van Maldergem,Pascale Hilbert,Anne Françoise Roux,Michel Mondain,Lies H. Hoefsloot,Cor W. R. J. Cremers,Tuija Löppönen,Heikki Löppönen,Agnete Parving,Karen Grønskov,Iris Schrijver,Joseph B. Roberson,Francesca Gualandi,Alessandro Martini,Geneviève Lina-Granade,Nathalie Pallares-Ruiz,Céu Correia,Graça Fialho,Kim Cryns,Nele Hilgert,Paul Van de Heyning,Carla Nishimura,Richard J.H. Smith,Guy Van Camp +63 more
TL;DR: The association between genotype and degree of hearing loss in persons with HI and biallelic GJB2 mutations was assessed and two genotypes had significantly more-severe HI than that of 35delG homozygotes.
Journal ArticleDOI
Occupational noise, smoking, and a high body mass index are risk factors for age-related hearing impairment and moderate alcohol consumption is protective: a European population-based multicenter study.
Erik Fransen,Vedat Topsakal,Jan Hendrickx,Lut Van Laer,Jeroen R. Huyghe,Els Van Eyken,Nele Lemkens,Samuli Hannula,Elina Mäki-Torkko,Mona Jensen,Kelly Demeester,Anke Tropitzsch,Amanda Bonaconsa,Manuela Mazzoli,Angeles Espeso,Katia Verbruggen,Joke Huyghe,Patrick L. M. Huygen,Sylvia J. W. Kunst,Minna Manninen,Amalia Diaz-Lacava,Michael Steffens,Thomas F. Wienker,Ilmari Pyykkö,Cor W. R. J. Cremers,Hannie Kremer,Ingeborg Dhooge,Dafydd Stephens,Eva Orzan,Markus Pfister,Michael Bille,Agnete Parving,Martti Sorri,Paul Van de Heyning,Guy Van Camp +34 more
TL;DR: The results suggest that a healthy lifestyle can protect against age-related hearing impairment and smoking significantly increased high-frequency hearing loss, and the effect was dose-dependent.
Journal ArticleDOI
A genotype-phenotype correlation for GJB2 (connexin 26) deafness.
Kim Cryns,Eva Orzan,Alessandra Murgia,Patrick L. M. Huygen,F Moreno,I del Castillo,G. Parker Chamberlin,Hela Azaiez,Sai Prasad,Robert A. Cucci,Emanuela Leonardi,Rikkert L. Snoeckx,Paul J. Govaerts,P. Van de Heyning,C M Van De Heyning,Richard J.H. Smith,G. Van Camp +16 more
TL;DR: This study is the first large systematic analysis indicating that the GJB2 genotype has a major impact on the degree of hearing impairment, and identifying mild genotypes.
Journal ArticleDOI
GRM7 variants confer susceptibility to age-related hearing impairment
Rick A. Friedman,Lut Van Laer,Matthew J. Huentelman,Sonal S. Sheth,Els Van Eyken,Jason J. Corneveaux,Waibhav Tembe,Rebecca F. Halperin,Ashley Q. Thorburn,Sofie Thys,Sarah Bonneux,Erik Fransen,Jeroen R. Huyghe,Ilmari Pyykkö,Cor W. R. J. Cremers,Hannie Kremer,Ingeborg Dhooge,Dafydd Stephens,Eva Orzan,Markus Pfister,Michael Bille,Agnete Parving,Martti Sorri,Paul Van de Heyning,Linna Makmura,Jeffrey D. Ohmen,Fred H. Linthicum,Jose N. Fayad,John V. Pearson,David Craig,Dietrich A. Stephan,Guy Van Camp +31 more
TL;DR: Results of the first whole genome association study for ARHI indicate that common alleles of GRM7 contribute to an individual's risk of developing ARHI, possibly through a mechanism of altered susceptibility to glutamate excitotoxicity.
Journal ArticleDOI
Cx26 deafness: mutation analysis and clinical variability
Alessandra Murgia,Eva Orzan,Roberta Polli,Maddalena Martella,Cinzia Vinanzi,Emanuela Leonardi,Edoardo Arslan,Franco Zacchello +7 more
TL;DR: Alterations of the Cx26 gene account for a large proportion of cases of congenital non-syndromic sensorineural deafness, so it seems appropriate to extend the molecular analysis even to subjects with mild or moderate prelingual hearing impairment of unknown cause.