E
Erik Schoenmakers
Researcher at Katholieke Universiteit Leuven
Publications - 11
Citations - 1014
Erik Schoenmakers is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Androgen receptor & Androgen. The author has an hindex of 9, co-authored 11 publications receiving 990 citations. Previous affiliations of Erik Schoenmakers include Catholic University of Leuven.
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Journal ArticleDOI
Selective DNA binding by the androgen receptor as a mechanism for hormone-specific gene regulation.
Frank Claessens,Guy Verrijdt,Erik Schoenmakers,Anna Haelens,Benjamin Peeters,Guido Verhoeven,Wilfried Rombauts +6 more
TL;DR: It seems that direct repeat elements can be the determinants of the AR-specificity, as it is demonstrated that the AR binds direct repeats of 5'-TGTTCT-3'-like sequences in gel retardation assays as well as in transfection experiments.
Journal ArticleDOI
Differential DNA binding by the androgen and glucocorticoid receptors involves the second Zn-finger and a C-terminal extension of the DNA-binding domains.
Erik Schoenmakers,Philippe Alen,Guy Verrijdt,Ben Peeters,Guido Verhoeven,Wilfried Rombauts,Frank Claessens +6 more
TL;DR: The data demonstrate that the mechanism by which the androgen receptor binds selectively to the PB-ARE-2 is different from that used by the glucocorticoid receptor to bind a consensus response element, and it is suggested that the androgens receptor recognizes response elements as a direct repeat rather than the classical inverted repeat.
Journal ArticleDOI
Differences in DNA binding characteristics of the androgen and glucocorticoid receptors can determine hormone-specific responses.
Erik Schoenmakers,Guy Verrijdt,Benjamin Peeters,Guido Verhoeven,Wilfried Rombauts,Frank Claessens +5 more
TL;DR: The influence of the DNA-binding domain on the specificity of androgen action is described and the novelty of the working hypothesis resides in the demonstration of the capacity of the AR-DNA- binding domain to recognize elements with a direct repeat structure.
Journal ArticleDOI
Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform.
Philippe Alen,Frank Claessens,Erik Schoenmakers,Johannes V. Swinnen,Guido Verhoeven,Wilfried Rombauts,Ben Peeters +6 more
TL;DR: Two isoforms of the putative coactivator ARA70/ELE1 that may act as a bridging factor between steroid receptors and components of the transcription initiation complex but which lack some fundamental properties of a classic nuclear receptor coactivators are identified.
Journal ArticleDOI
Change of specificity mutations in androgen-selective enhancers. Evidence for a role of differential DNA binding by the androgen receptor.
Guy Verrijdt,Erik Schoenmakers,Anna Haelens,Benjamin Peeters,Guido Verhoeven,Wilfried Rombauts,Frank Claessens +6 more
TL;DR: It is demonstrated that differential recognition by the androgen receptor of nonconventional steroid response elements is, at least in some cases, an important mechanism in androgen-specific transcriptional regulation.