J
Johannes V. Swinnen
Researcher at Katholieke Universiteit Leuven
Publications - 175
Citations - 14386
Johannes V. Swinnen is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Androgen & LNCaP. The author has an hindex of 61, co-authored 153 publications receiving 11954 citations. Previous affiliations of Johannes V. Swinnen include The Catholic University of America & University of North Carolina at Chapel Hill.
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Journal ArticleDOI
EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research
Jan Van Deun,Pieter Mestdagh,Patrizia Agostinis,Özden Akay,Sushma Anand,Jasper Anckaert,Zoraida Andreu Martinez,Tine Baetens,Els Beghein,Laurence Bertier,Geert Berx,Janneke Boere,Stephanie Boukouris,Michel Bremer,Dominik Buschmann,James Brian Byrd,Clara Casert,Lesley Cheng,Anna Cmoch,Delphine Daveloose,Eva De Smedt,Seyma Demirsoy,Victoria Depoorter,Bert Dhondt,Tom A. P. Driedonks,Aleksandra M. Dudek,Abdou ElSharawy,Ilaria Floris,Andrew D Foers,Kathrin Gärtner,Abhishek D. Garg,Edward Geeurickx,Jan Gettemans,Farzaneh Ghazavi,Bernd Giebel,Tom Groot Kormelink,Grace V. Hancock,Hetty Helsmoortel,Andrew F. Hill,Vincent Hyenne,Hina Kalra,David Kim,Joanna Kowal,Joanna Kowal,Sandra Kraemer,Petra Leidinger,Carina Leonelli,Yaxuan Liang,Lien Lippens,Shu Liu,Alessandra Lo Cicero,Alessandra Lo Cicero,Shaun Martin,Suresh Mathivanan,Prabhu Mathiyalagan,Tamás Matusek,Gloria Milani,Marta Monguió-Tortajada,Liselot Mus,Dillon C. Muth,Andrea Németh,Esther N. M. Nolte-‘t Hoen,Lorraine O'Driscoll,Roberta Palmulli,Roberta Palmulli,Michael W. Pfaffl,Bjarke Primdal-Bengtson,Bjarke Primdal-Bengtson,Erminia Romano,Quentin Rousseau,Susmita Sahoo,Natalia G. Sampaio,Monisha Samuel,Benjamin J. Scicluna,Bieke Soen,Anneleen Steels,Johannes V. Swinnen,Maarit Takatalo,Safia Thaminy,Clotilde Théry,Clotilde Théry,Joeri Tulkens,Isabel Van Audenhove,Susanne G. van der Grein,Alan Van Goethem,Martijn J. C. van Herwijnen,Guillaume van Niel,Guillaume van Niel,Nadine Van Roy,Alexander R. van Vliet,Niels Vandamme,Suzanne Vanhauwaert,Glenn Vergauwen,Frederik J. Verweij,Frederik J. Verweij,Annelynn Wallaert,Marca H. M. Wauben,Kenneth W. Witwer,Marijke I. Zonneveld,Olivier De Wever,Jo Vandesompele,An Hendrix +101 more
TL;DR: It is argued that the field of extracellular vesicle (EV) biology needs more transparent reporting to facilitate interpretation and replication of experiments and EV-TRACK, a crowdsourcing knowledgebase that centralizes EV biology and methodology, is described.
Journal ArticleDOI
A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis.
Karel De Gendt,Johannes V. Swinnen,Philippa T. K. Saunders,Luc Schoonjans,Mieke Dewerchin,Ann Devos,Karen Tan,Nina Atanassova,Frank Claessens,Charlotte Lécureuil,Walter Heyns,Peter Carmeliet,Florian Guillou,Richard M. Sharpe,Guido Verhoeven +14 more
TL;DR: It is concluded that cell-autonomous action of the AR in SC is an absolute requirement for androgen maintenance of complete spermatogenesis, and that sPermatocyte/spermatid development/survival critically depends on androgens.
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De novo Lipogenesis Protects Cancer Cells from Free Radicals and Chemotherapeutics by Promoting Membrane Lipid Saturation
Evelien Rysman,Koen Brusselmans,Katryn Scheys,Leen Timmermans,Rita Derua,Sebastian Munck,Paul P. Van Veldhoven,David Waltregny,Veerle W. Daniels,Jelle Machiels,Frank Vanderhoydonc,Karine Smans,Etienne Waelkens,Guido Verhoeven,Johannes V. Swinnen +14 more
TL;DR: Evidence is provided that shifting lipid acquisition from lipid uptake toward de novo lipogenesis dramatically changes membrane properties and protects cells from both endogenous and exogenous insults, and provides a rationale for the use of lipogenesis inhibitors as antineoplastic agents and as chemotherapeutic sensitizers.
Journal ArticleDOI
Increased lipogenesis in cancer cells: new players, novel targets
TL;DR: Not only fatty acid synthase, but in fact all key enzymes involved in fatty acid synthesis as well as key metabolic regulators are potential targets for antineoplastic intervention.
Journal ArticleDOI
Induction of Cancer Cell Apoptosis by Flavonoids Is Associated with Their Ability to Inhibit Fatty Acid Synthase Activity
TL;DR: The findings indicate that the potential of flavonoids to induce apoptosis in cancer cells is strongly associated with their FAS inhibitory properties, thereby providing a new mechanism by which polyphenolic compounds may exert their cancer-preventive and antineoplastic effects.