Ernestine Lee

TL;DR: A comprehensive set of recombinant secreted proteins and the extracellular domains of transmembrane proteins, which constitute most of the protein components of the Extracellular space, are produced, useful for discovering new ligands and receptors and assessing the functional selectivity ofextracellular regulatory proteins.

TL;DR: In this paper, the authors propose a common dynamical origin for these compositional and orbital properties based on four-body simulations in the Hill approximation, and predict that a sizeable population of very unequal-mass Kuiper-belt binaries is probably awaiting discovery.

TL;DR: In this paper, the authors provide FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis.

TL;DR: Isolated fibroblast growth factor receptor 1 (FGFR1), FGFR2, FGFR3, and FGFR4 polypeptides and polynucleotides encoding the FGFR1-4 are described in this article.

TL;DR: This work discovered the ligands for the orphan receptor leukocyte tyrosine kinase with the first case in which secreted factor ligands were identified for an orphan receptor with this technique, using a strategy of screening the extracellular proteome, one protein at a time.