Kevin Hestir

TL;DR: A comprehensive set of recombinant secreted proteins and the extracellular domains of transmembrane proteins, which constitute most of the protein components of the Extracellular space, are produced, useful for discovering new ligands and receptors and assessing the functional selectivity ofextracellular regulatory proteins.

TL;DR: A soluble FGF receptor Fc fusion protein (FP-1039) is designed that binds tightly to all of the mitogenic FGF ligands, inhibits FGF-stimulated cell proliferation in vitro, blocks FGF– and vascular endothelial growth factor–induced angiogenesis in vivo, and inhibits in vivo growth of a broad range of tumor types.

TL;DR: In this paper, the authors provide FGFR fusion proteins, methods of making them, and methods of using them to treat proliferative disorders, including cancers and disorders of angiogenesis.

TL;DR: Isolated fibroblast growth factor receptor 1 (FGFR1), FGFR2, FGFR3, and FGFR4 polypeptides and polynucleotides encoding the FGFR1-4 are described in this article.

TL;DR: This work discovered the ligands for the orphan receptor leukocyte tyrosine kinase with the first case in which secreted factor ligands were identified for an orphan receptor with this technique, using a strategy of screening the extracellular proteome, one protein at a time.