Haishan Lin

TL;DR: A comprehensive set of recombinant secreted proteins and the extracellular domains of transmembrane proteins, which constitute most of the protein components of the Extracellular space, are produced, useful for discovering new ligands and receptors and assessing the functional selectivity ofextracellular regulatory proteins.

TL;DR: In this article, the action and expression of IL-34, a novel CSF-1R ligand, were investigated in the mouse, and it was shown that IL34 mRNA was strongly expressed in the embryonic brain at E11.5, prior to the expression of Csf1 mRNA.

TL;DR: Compared to wild type mice, CSF-1R-deficient mice have smaller brains of greater mass and ablation of the Csf1r gene in Nestin-positive neural progenitors led to a smaller brain size, an expanded Neural progenitor pool and elevated cellular apoptosis in cortical forebrain, indicating novel roles for the CSF/IL-34 receptor in the regulation of corticogenesis.

TL;DR: This study identified receptor-type protein-tyrosine phosphatase ζ (PTP-ζ), a cell surface chondroitin sulfate (CS) proteoglycan, as a novel IL-34 receptor that may mediate its action on novel cellular targets.

TL;DR: Functional dissection of theIL-34:CSF-1R interface indicates that the hydrophobic interactions, rather than the salt bridge network, dominate the biological activity of IL-34, and to degenerately recognize two ligands with completely different surfaces, CSF- 1R apparently takes advantage of different subsets of a chemically inert surface that can be tuned to fit different ligand shapes.