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Ernst N.H. Jansen Steur
Researcher at Medisch Spectrum Twente
Publications - 23
Citations - 10096
Ernst N.H. Jansen Steur is an academic researcher from Medisch Spectrum Twente. The author has contributed to research in topics: Parkinson's disease & Nicotinic agonist. The author has an hindex of 18, co-authored 23 publications receiving 8908 citations.
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Journal ArticleDOI
Staging of brain pathology related to sporadic Parkinson’s disease
TL;DR: This study traces the course of the pathology in incidental and symptomatic Parkinson cases proposing a staging procedure based upon the readily recognizable topographical extent of the lesions.
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Pathological features of cerebral cortical capillaries are doubled in Alzheimer's disease and Parkinson's disease
TL;DR: The data indicate that basement membrane deposists, as opposed to pericytic degeneration, represent an important pathological feature of AD and PD and suggest that capillary dysfunction may play a causal role in the development of these two major neurodegenerative diseases.
Journal ArticleDOI
Quantitative assessment of nicotinic acetylcholine receptor proteins in the cerebral cortex of Alzheimer patients
Lothar Burghaus,Ulrich Schütz,Udo Krempel,Rob A.I. de Vos,Ernst N.H. Jansen Steur,Andrea Wevers,Jon Lindstrom,Hannsjörg Schröder +7 more
TL;DR: The quantitative assessment of nicotinic acetylcholine receptor expression will help to determine those subunits suited as targets for pharmacological stimulation in Alzheimer's disease and severe cognitive deficits.
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Disease-specific accumulation of mutant ubiquitin as a marker for proteasomal dysfunction in the brain
David F. Fischer,Rob A.I. de Vos,Renske van Dijk,Femke M.S. de Vrij,Evelien A. Proper,M. A. F. Sonnemans,Marian C. Verhage,Jacqueline A. Sluijs,Barbara Hobo,Mohamed Zouambia,Ernst N.H. Jansen Steur,Wouter Kamphorst,Elly M. Hol,Fred W. van Leeuwen +13 more
TL;DR: The finding that UBB+1 protein only accumulates in tauopathies thus implies that the ubiquitin‐proteasome system is impaired specifically in this group of neurodegenerative diseases and not in synucleinopathies and that the presence of UBB-1 protein reports proteasomal dysfunction in the brain.
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Increase of Parkinson disability after fluoxetine medication
TL;DR: The increased amount of motor disability in four patients with idiopathic Parkinson's disease after exposure to the antidepressant fluoxetine is reported.