E
Erwin Lamping
Researcher at University of Otago
Publications - 38
Citations - 2071
Erwin Lamping is an academic researcher from University of Otago. The author has contributed to research in topics: Efflux & ATP-binding cassette transporter. The author has an hindex of 17, co-authored 34 publications receiving 1836 citations.
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Journal ArticleDOI
Efflux-Mediated Antifungal Drug Resistance
Richard D. Cannon,Erwin Lamping,Ann R. Holmes,Kyoko Niimi,Philippe Baret,Mikhail V. Keniya,Koichi Tanabe,Masakazu Niimi,André Goffeau,Brian C. Monk +9 more
TL;DR: Phylogenetic analysis of the ABC pleiotropic drug resistance family has provided a new view of the evolution of this important class of efflux pumps, and potential therapeutic approaches that could overcome azole resistance are proposed.
Journal ArticleDOI
Candida albicans drug resistance another way to cope with stress
Richard D. Cannon,Erwin Lamping,Ann R. Holmes,Kyoko Niimi,Koichi Tanabe,Masakazu Niimi,Brian C. Monk +6 more
TL;DR: This article examines C. albicans drug resistance from the perspective of it being a stress response and investigates how commonality with other stress-response pathways gives insights into the prospects for overcoming, or preventing, drug resistance.
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Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces cerevisiae.
Erwin Lamping,Brian C. Monk,Kyoko Niimi,Ann R. Holmes,Sarah Tsao,Koichi Tanabe,Masakazu Niimi,Yoshimasa Uehara,Richard D. Cannon +8 more
TL;DR: The use of a modified membrane protein hyperexpression system to characterize three classes of fungal membrane proteins that contribute to the drug resistance phenotypes of five pathogenic fungi and to express human P glycoprotein.
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ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates.
Ann R. Holmes,Ya-Hsun Lin,Kyoko Niimi,Erwin Lamping,Mikhail V. Keniya,Masakazu Niimi,Koichi Tanabe,Brian C. Monk,Richard D. Cannon +8 more
TL;DR: Cdr1p expression makes a greater functional contribution than does Cdr2p to FLC resistance in C. albicans, and compounds that inhibited both pumps did not cause increased chemosensitization of these strains to F LC.
Journal ArticleDOI
Fungal PDR transporters: Phylogeny, topology, motifs and function.
TL;DR: Unique structural elements are predicted, new PDR-specific motifs identified, and the significance of these and other structural features discussed are discussed.