Kyoko Niimi

TL;DR: Phylogenetic analysis of the ABC pleiotropic drug resistance family has provided a new view of the evolution of this important class of efflux pumps, and potential therapeutic approaches that could overcome azole resistance are proposed.

TL;DR: This article examines C. albicans drug resistance from the perspective of it being a stress response and investigates how commonality with other stress-response pathways gives insights into the prospects for overcoming, or preventing, drug resistance.

TL;DR: The controlled overexpression of C. albicansCdr1p in an S. cerevisiae background deficient in other pumps allows the functional analysis of pumping specificity and mechanisms of a major ABC transporter involved in drug efflux from an important human pathogen.

TL;DR: The use of a modified membrane protein hyperexpression system to characterize three classes of fungal membrane proteins that contribute to the drug resistance phenotypes of five pathogenic fungi and to express human P glycoprotein.

TL;DR: Cdr1p expression makes a greater functional contribution than does Cdr2p to FLC resistance in C. albicans, and compounds that inhibited both pumps did not cause increased chemosensitization of these strains to F LC.