Richard D. Cannon

TL;DR: Phylogenetic analysis of the ABC pleiotropic drug resistance family has provided a new view of the evolution of this important class of efflux pumps, and potential therapeutic approaches that could overcome azole resistance are proposed.

TL;DR: Candida albicans is frequently isolated from the human mouth, yet few carriers develop clinical signs of candidiasis, which results from yeast overgrowth and penetration of the oral tissues when the host's physical and immunological defenses have been undermined.

TL;DR: The relatively small number of commensal Candida cells in the oral flora raises the possibility that strategies can be devised to prevent oral colonization and infection, but the variety of oral niches and the complex adherence mechanisms of the yeast mean that such a goal will remain elusive until more is known about the contribution of each mechanism.

TL;DR: The results suggest that fluconazole enters C. albicans cells by facilitated diffusion and that flu Conazole resistance may involve energy-dependent drug efflux associated with increased expression of Benr and/or Cdr1.

TL;DR: In this article, the authors report crystal structures of full-length Saccharomyces cerevisiae lanosterol 14α-demethylase, a membrane monospanning cytochrome P450 of the CYP51 family that catalyzes the first postcyclization step in ergosterol biosynthesis and is inhibited by triazole drugs.