Showing papers by "Erwin Neher published in 1996"
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TL;DR: PMA treatment leads to a large increase in amplitude, but little change in the time course of the exocytic burst that results from rapid elevation of [Ca2+]i upon photolysis of DMI-Nitrophen, so PKC appears to affect a late step in secretion but not the Ca2+ sensitivity of the final step.
394 citations
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TL;DR: Capacitance measurements and the single-cell immunoblot assay found that the somata underwent robust exocytosis upon depolarization and released substance P, in response to KCl stimulation, suggesting that soma release is Ca(2+)-dependent.
276 citations
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TL;DR: The persistence of secretion after a depolarization is reduced by addition of mobile calcium buffer, implying that Ca2+ channels and secretory vesicles are not colocalized in chromaffin cells, in contrast to presynaptic active zones.
146 citations