T
Tobias Moser
Researcher at University of Göttingen
Publications - 198
Citations - 13504
Tobias Moser is an academic researcher from University of Göttingen. The author has contributed to research in topics: Hair cell & Ribbon synapse. The author has an hindex of 63, co-authored 174 publications receiving 11634 citations. Previous affiliations of Tobias Moser include Max Planck Society & German Primate Center.
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Journal ArticleDOI
Otoferlin, Defective in a Human Deafness Form, Is Essential for Exocytosis at the Auditory Ribbon Synapse
Isabelle Roux,Saaid Safieddine,Régis Nouvian,M'hamed Grati,M'hamed Grati,Marie-Christine Simmler,Amel Bahloul,Isabelle Perfettini,Morgane Le Gall,Philippe Rostaing,Ghislaine Hamard,Antoine Triller,Paul Avan,Tobias Moser,Christine Petit +14 more
TL;DR: Otoferlin is essential for a late step of synaptic vesicle exocytosis and may act as the major Ca(2+) sensor triggering membrane fusion at the IHC ribbon synapse.
Journal ArticleDOI
Hair cell synaptic ribbons are essential for synchronous auditory signalling
Darina Khimich,Régis Nouvian,Régis Nouvian,Rémy Pujol,Susanne tom Dieck,Susanne tom Dieck,Alexander Egner,Eckart D. Gundelfinger,Tobias Moser +8 more
TL;DR: It is concluded that ribbon-dependent synchronous release of multiple vesicles at the hair cell afferent synapse is essential for normal hearing.
Journal ArticleDOI
Kinetics of exocytosis and endocytosis at the cochlear inner hair cell afferent synapse of the mouse
Tobias Moser,Dirk Beutner +1 more
TL;DR: The presynaptic function of single mouse IHCs is studied by monitoring membrane capacitance changes and voltage-gated Ca(2+) currents and the observed secretory depression is interpreted as depletion of a readily releasable pool (RRP) of about 280 vesicles.
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Munc18-1 promotes large dense-core vesicle docking.
Thomas Voets,Ruud F. Toonen,Elisabeth C. Brian,Heidi de Wit,Tobias Moser,Tobias Moser,Jens Rettig,Thomas C. Südhof,Erwin Neher,Matthijs Verhage +9 more
TL;DR: It is concluded that Munc18-1 functions upstream of SNARE complex formation and promotes LDCV docking, which increases the amount of releasable vesicles and accelerated vesicle supply.
Journal ArticleDOI
CaV1.3 Channels Are Essential for Development and Presynaptic Activity of Cochlear Inner Hair Cells
TL;DR: It is concluded that CaV1.3 channels are essential for normal hair cell development and synaptic transmission and a lack of functional large-conductance Ca2+-activated K+ channels up to 4 weeks after birth.