Esmée Adegeest

TL;DR: A single-cell transcriptomics study of the human fetal kidney is presented, identifying 22 cell types and a host of marker genes and exploring the heterogeneity of the nephrogenic niche, localized podocyte precursors, and confirmed disease-associated marker genes.

TL;DR: This study shows that assemblies of mouse ESCs and extraembryonic endoderm cells can develop beyond gastrulation and produce a central hallmark of organogenesis: stratified neural epithelia resembling a neural tube, which can be further differentiated to cerebral cortex-like tissue.

TL;DR: This article showed that adding extra embryonic endoderm (XEN) cells to mouse gastruloids leads to the formation of neural epithelia, and further showed that the XEN cells differentiate reciprocally to a visceral endodererm-like state.

TL;DR: These XEN-enhanced gastruloids (XEGs) are established to explore heterotypic cellular interactions and their developmental consequences in vitro and it is demonstrated that local inhibition of WNT signaling and production of a basement membrane by the XEN cells underlie the formation of the neuroepithelial tissue.

TL;DR: In this article , a combination of convergent extension and differential adhesion was used to explain the observed shapes of 3D gastruloid shapes, which can be used to elucidate morphogenic processes in embryonic development.