M
Monika Bialecka
Researcher at Leiden University Medical Center
Publications - 24
Citations - 1434
Monika Bialecka is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 17, co-authored 24 publications receiving 1067 citations. Previous affiliations of Monika Bialecka include University of Cambridge & Utrecht University.
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Journal ArticleDOI
Cdx and Hox Genes Differentially Regulate Posterior Axial Growth in Mammalian Embryos
Teddy Young,Jennifer E. Rowland,Cesca van de Ven,Monika Bialecka,Ana Nóvoa,Marta Carapuço,Johan van Nes,Wim de Graaff,Isabelle Duluc,Jean-Noël Freund,Felix Beck,Moisés Mallo,Moisés Mallo,Jacqueline Deschamps +13 more
TL;DR: Hox genes seem to differentially orchestrate posterior expansion of embryonic tissues during axial morphogenesis as an integral part of their function in specifying head-to-tail identity.
Journal ArticleDOI
In vitro culture of mouse blastocysts beyond the implantation stages
Ivan Bedzhov,Chuen Yan Leung,Chuen Yan Leung,Monika Bialecka,Monika Bialecka,Magdalena Zernicka-Goetz,Magdalena Zernicka-Goetz +6 more
TL;DR: A protocol supporting the development of the mouse embryo beyond the blastocyst stage in vitro, which allows observation of a previously hidden period of development and provides a platform for novel research into peri-implantation embryogenesis and beyond.
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Single-cell transcriptomics reveals gene expression dynamics of human fetal kidney development.
Mazène Hochane,Patrick R. van den Berg,Xueying Fan,Noémie M. L. P. Bérenger-Currias,Esmée Adegeest,Monika Bialecka,Maaike Nieveen,Maarten Menschaart,Susana M. Chuva de Sousa Lopes,Susana M. Chuva de Sousa Lopes,Stefan Semrau +10 more
TL;DR: A single-cell transcriptomics study of the human fetal kidney is presented, identifying 22 cell types and a host of marker genes and exploring the heterogeneity of the nephrogenic niche, localized podocyte precursors, and confirmed disease-associated marker genes.
Journal ArticleDOI
Single-cell reconstruction of follicular remodeling in the human adult ovary.
Xueying Fan,Monika Bialecka,Ioannis Moustakas,Eric Lam,Vanessa Torrens-Juaneda,N. V. Borggreven,L. Trouw,L. A. Louwe,Gonneke S. K. Pilgram,Hailiang Mei,L. van der Westerlaken,S M Chuva de Sousa Lopes,S M Chuva de Sousa Lopes +12 more
TL;DR: By performing single cell RNA-sequencing of adult human follicles, the authors identify subclasses of granulosa and theca cell lineages, which correlate with the growth or degeneration of the follicles.
Journal ArticleDOI
Cdx2 determines the fate of postnatal intestinal endoderm
Emma J. Stringer,Isabelle Duluc,Thoueiba Saandi,Irwin Davidson,Monika Bialecka,Toshiro Sato,Nick Barker,Hans Clevers,Catrin Pritchard,Doug J. Winton,Nicholas A. Wright,Jean-Noël Freund,Jacqueline Deschamps,Felix Beck +13 more
TL;DR: It is concluded that expression of Cdx2 is essential for differentiation of gut stem cells into any of the intestinal cell types, but they maintain a degree of cell-autonomous plasticity that allows them to switch on a variety of gastric genes.