Esther Castillo-Gómez

TL;DR: The MAP-ERK pathway is a key element of the neuroinflammatory pathway triggered by glial cells during the development of neurodegenerative diseases, such as Parkinson's and Alzheimer's disease, Huntington’s disease, and amyotrophic lateral sclerosis, as well as prionic diseases.

TL;DR: In this article, a set of macros for automated fluorescence analysis of large batches of fixed tissue samples using FIJI/ImageJ is described and shared, which can be easily modified to improve similar analysis of fluorescent probes in human biopsies for diagnostic purposes.

TL;DR: In this article, a chronic peripubertal stress (PPS) protocol based on psychogenic stressors was applied to male and diestrus females to analyze the long-term effects of PPS on the excitatory and inhibitory circuitry of the adult prefrontal cortex (PFC), and whether these effects are sex-dependent.

TL;DR: This review summarizes recent findings from stress research and provides an overview of its age-dependent effects on the structure and function of the amygdala, which includes molecular and cellular changes, and how they can trigger deviant social and affective behaviors.

TL;DR: The nucleus incertus of the pontine tegmentum provides a strong GABAergic and peptidergic innervation of the hippocampus, basal forebrain, amygdala, prefrontal cortex, and related regions; and represents a parallel source of ascending modulation of cognitive and emotional domains.