E
Ethan Ford
Researcher at Massachusetts Institute of Technology
Publications - 7
Citations - 3145
Ethan Ford is an academic researcher from Massachusetts Institute of Technology. The author has contributed to research in topics: Promoter & Epigenomics. The author has an hindex of 4, co-authored 4 publications receiving 2888 citations.
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Journal ArticleDOI
Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6
Raul Mostoslavsky,Katrin F. Chua,Katrin F. Chua,David B. Lombard,Wendy W. Pang,Miriam R. Fischer,Lionel Gellon,Pingfang Liu,Gustavo Mostoslavsky,Sonia Franco,Michael M. Murphy,Kevin D. Mills,Parin Patel,Joyce T. Hsu,Andrew L. Hong,Ethan Ford,Hwei Ling Cheng,Caitlin Kennedy,Nomeli P. Nunez,Nomeli P. Nunez,Roderick T. Bronson,David Frendewey,Wojtek Auerbach,David M. Valenzuela,Margaret Karow,Michael O. Hottiger,Stephen D. Hursting,J. Carl Barrett,J. Carl Barrett,Leonard Guarente,Richard C. Mulligan,Bruce Demple,George D. Yancopoulos,Frederick W. Alt +33 more
TL;DR: It is demonstrated that SIRT6 is a nuclear, chromatin-associated protein that promotes resistance to DNA damage and suppresses genomic instability in mouse cells, in association with a role in base excision repair (BER).
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Calorie restriction extends yeast life span by lowering the level of NADH
TL;DR: It is shown that CR decreases NADH levels, and that NADH is a competitive inhibitor of Sir2, validating the model that NADh regulates yeast longevity in response to CR.
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Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription
TL;DR: The findings suggest that SIRT7 is a positive regulator of Pol I transcription and is required for cell viability in mammals.
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Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase.
TL;DR: Results provide the first characterization of a Sir2 protein from phylogenetic class IV, and it is observed that the catalytic mechanism of this reaction is intra-molecular, with individual molecules of mSIRT6 directing their own modification.
Journal ArticleDOI
Large-scale manipulation of promoter DNA methylation reveals context-specific transcriptional responses and stability
Alexandre de Mendoza,Trung Nguyen,Ethan Ford,Daniel Poppe,Sam Buckberry,Jahnvi Pflueger,Matthew R. Grimmer,Sabine Stolzenburg,Ozren Bogdanovic,Alicia Oshlack,Peggy J. Farnham,Pilar Blancafort,Ryan Lister +12 more
TL;DR: In this paper , the effect of DNA methylation on endogenous promoters has been comprehensively assessed using an engineered zinc finger-DNMT3A fusion protein, enabling them to test the effect on transcription, chromatin accessibility and histone modifications after the removal of the fusion protein.