Euan M. Slorach

TL;DR: It is suggested that GATA-3 actively maintains luminal epithelial differentiation in the adult mammary gland, which raises important implications for the pathogenesis of breast cancer.

TL;DR: It is shown that tumor dissemination and metastasis occur in discrete steps during tumor progression, and targeted deletion of GATA-3 in early tumors led to apoptosis of differentiated cells, indicating that its loss is not sufficient for malignant conversion.

TL;DR: Results indicate that Zeppo1 is a key regulator of breast cancer progression and overexpression in a mouse breast cancer model increases lung metastases, while reducingZeppo1 expression reduces both tumor size and the number of Lung metastases.

TL;DR: This work has identified zinc-finger elbow-related proline domain protein 2 (ZPO2) as a transcriptional repressor that down-regulates GATA3 and promotes aggressive breast cancer, and identifies ZPO2 as a possible candidate gene for future diagnostic and therapeutic strategies.

TL;DR: The findings suggest that ZPO2 plays a significant role in mammary gland homeostasis and that deregulation of Zpo2 may promote breast cancer development, and that overexpression of Z po2 in MMTV-PyMT mammary tumor cell lines enhances lung metastasis.