Showing papers in "Cancer Cell in 2008"

TL;DR: The peculiarities of tumor cell metabolism are reviewed to discuss the alterations in signal transduction pathways and/or enzymatic machineries that account for metabolic reprogramming of transformed cells.

TL;DR: This study characterized cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) cell lines, tumor specimens, and blood samples, and identified a more aggressive phenotype than the CD90+CD44(-) counterpart and formed metastatic lesions in the lung of immunodeficient mice.

TL;DR: It is shown that tumor cells can disseminate systemically from earliest epithelial alterations in HER-2 and PyMT transgenic mice and from ductal carcinoma in situ in women, and release from dormancy of early-disseminated cancer cells may frequently account for metachronous metastasis.

TL;DR: It is demonstrated that HIF1alpha, the direct effector of hypoxia, partly through increases in SDF1 alpha, induces recruitment of bone marrow-derived CD45+ myeloid cells containing Tie2+, VEGFR1+, CD11b+, and F4/80+ subpopulations, as well as endothelial and pericyte progenitor cells to promote neovascularization in glioblastoma.

TL;DR: It is demonstrated that Gr-1+CD11b+ myeloid cells are recruited into mammary carcinomas with type II TGF beta receptor gene (Tgfbr2) deletion and directly promote tumor metastasis.

TL;DR: In this article, the miR-106b-25 cluster, upregulated in a subset of human gastric tumors, is activated by E2F1 in parallel with its host gene, Mcm7.

TL;DR: An automated time-lapse light microscopy approach is used to systematically analyze over 10,000 single cells from 15 cell lines in response to three different classes of antimitotic drug, showing that the variation in cell behavior is far greater than previously recognized.

TL;DR: Using real-time RT-PCR, the authors obtained microRNA expressions in 112 NSCLC patients, which were divided into the training and testing sets, and used Cox regression and risk-score analysis to identify a five microRNA signatures for the prediction of treatment outcome.

TL;DR: It is demonstrated that Sirt1(+/-) mice develop tumors in multiple tissues, whereas activation of SIRT1 by resveratrol treatment reduces tumorigenesis, and it is shown that many human cancers exhibit reduced levels ofSIRT1 compared to normal controls.

TL;DR: It is demonstrated that pathologic elevation of a single proinflammatory cytokine may be sufficient to induce neoplasia and provide a direct link between IL-1beta, MDSCs, and carcinogenesis.

TL;DR: Treatment with rapamycin that led to further Aktactivation and resistance to etoposide hypersensitized cancer cells to ROS-mediated apoptosis constitutes a strategy for cancer therapy that selectively eradicates cancer cells via Akt activation.

TL;DR: It is shown that a large fraction of human cancers overexpress Twist1 and/or Twist2, suggesting an unanticipated direct link between early escape from failsafe programs and the acquisition of invasive features by cancer cells.

TL;DR: It is suggested that medulloblastoma can be initiated in progenitors or stem cells but that Shh-induced tumorigenesis is associated with neuronal lineage commitment.

TL;DR: It is shown in human and mouse medulloblastoma that cells expressing the glia-associated markers Gfap and Olig2 are neoplastic and retain features of embryonic-type granule lineage progenitors, indicating that acquisition of CGNP identity is essential for tumorigenesis.

TL;DR: Reconstitution of miR-29 in RMS in mice inhibits tumor growth and stimulates differentiation, suggesting that mi R-29 acts as a tumor suppressor through its promyogenic function.

TL;DR: It is demonstrated that ectopic H3K79 methylation is a distinguishing feature of murine and human MLL-AF4 ALLs and is important for maintenance of MLL -AF4-driven gene expression.

TL;DR: In this paper, the authors show that the signaling adaptor p62 is induced by Ras, its levels are increased in human tumors, and it is required for Ras-induced survival and transformation.

TL;DR: The role of myoepithelial cells and fibroblasts in the progression of in situ carcinomas using a model of human DCIS and primary breast tumors was analyzed to identify an intricate interaction network involving TGFbeta, Hedgehog, cell adhesion, and p63 required for myoEPithelial cell differentiation.

TL;DR: It is shown that Hedgehog signaling is activated in LSCs through upregulation of Smo, and this indicates that Smo inhibition might be an effective treatment strategy to reduce the LSC pool in CML.

TL;DR: A portrait of the HECT E3s is provided, through the development of small-molecule inhibitors, as an anticancer therapeutic strategy, to link the substrate specificity of HECT-type E 3s with their contribution to tumorigenesis.

TL;DR: It is demonstrated here that menin's ability to serve as a molecular adaptor that physically links the MLL (mixed-lineage leukemia) histone methyltransferase with LEDGF (lens epithelium-derived growth factor) puts it at the nexus of transcriptional pathways that are recurrently targeted in diverse diseases.

TL;DR: It is shown that tenovins act through inhibition of the protein-deacetylating activities of SirT1 and SirT2, two important members of the sirtuin family, and underscores the utility of these compounds as biological tools for the study of sIRTuin function as well as their potential therapeutic interest.

TL;DR: In this article, the effects of hypoxia-inducible factor alpha (HIF-alpha) stabilization on c-Myc activity in sporadic clear cell renal carcinomas (ccRCCs) were investigated.

TL;DR: In human cancer cells, the function of kinase-independent EGFR is to prevent autophagic cell death by maintaining intracellular glucose level through interaction and stabilization of the sodium/glucose cotransporter 1 (SGLT1).

TL;DR: Hepatocyte-specific p38 alpha ablation enhanced ROS accumulation and liver damage, which were prevented upon administration of an antioxidant, and IL-1 alpha release by necrotic hepatocytes is therefore an important mediator of liver tumorigenesis.

TL;DR: It is reported that a fragile chromosomal region lost in specific hematopoietic malignancies, miR-203, functions as a tumor suppressor, and re-expression of this microRNA might have therapeutic benefits in specifichematopOieticmalignancies.

TL;DR: It is shown that certain chemotherapy drugs, e.g., paclitaxel, can rapidly induce proangiogenic bone marrow-derived circulating endothelial progenitor (CEP) mobilization and subsequent tumor homing, whereas others do not.

TL;DR: It is demonstrated that a small regulatory microRNA, miR-296, has a major role in angiogenesis by directly targeting the hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) mRNA, leading to decreased levels of HGS and thereby reducing HGS-mediated degradation of the growth factor receptors VEGFR2 and PDGFRbeta.

TL;DR: The Hippo pathway defined originally in Drosophila melanogaster is conserved in mammals and is established as one major conserved mechanism governing cell contact inhibition, organ size control, and cancer development.

TL;DR: It is demonstrated that both bone morphogenetic protein (BMP)-mediated and ciliary neurotrophic factor (CNTF)-mediated Jak/STAT-dependent astroglial differentiation is impaired due to EZH2-dependent epigenetic silencing of BMP receptor 1B (BMPR1B) in a subset of glioblastoma TICs.