Eun Ho Meang

TL;DR: Investigation of the toxic effect of 100 nm negatively or positively charged zinc oxide NPs administered by gavage in Sprague Dawley rats established a no observed adverse effect level, and identified target organ(s) to be the stomach, pancreas, eye, and prostate gland, to speculate that this inflammatory damage might result from continuous irritation caused by both test articles.

TL;DR: The results of this study indicate that the NOAEL forSiO2EN20(−) and SiO2 EN100(−), administered by gavage in Sprague-Dawley rats, would most likely be 2,000 mg/kg, and no target organ was identified in rats of either sex.

TL;DR: Evaluation of the “no observed adverse effect level” and systemic toxicities of all NPs were performed by thorough evaluation steps and the toxicokinetics step, which included in vivo studies with zinc oxide and silica NPs.

TL;DR: Treatment with 20-nm, negatively-charged ZnO NPs increased retinopathy, associated with local distribution of them in ocular lesions, and revealed decreased neurons of the ganglion cell layer of animals treated with Zn O NPs compared to the control group.