E
Eva Gonczol
Researcher at Wistar Institute
Publications - 88
Citations - 5392
Eva Gonczol is an academic researcher from Wistar Institute. The author has contributed to research in topics: Human cytomegalovirus & Virus. The author has an hindex of 34, co-authored 88 publications receiving 5321 citations. Previous affiliations of Eva Gonczol include University of Szeged & Albert Szent-Györgyi Medical University.
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Journal ArticleDOI
Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy
TL;DR: Approaches for improving recombinant adenoviruses that are based on further crippling the virus to limit expression of nondeleted viral genes are suggested.
Journal ArticleDOI
Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis.
Yiping Yang,Yiping Yang,Frederick A. Nunes,Frederick A. Nunes,Klara Berencsi,Eva Gonczol,John F. Engelhardt,John F. Engelhardt,James M. Wilson,James M. Wilson +9 more
TL;DR: It is shown that with first generation adenovirus–mediated gene transfer to the mouse lung, viral proteins are expressed leading to destructive cellular immune responses and repopulation of the lung with nontransgene containing cells.
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Cytomegalovirus replicates in differentiated but not in undifferentiated human embryonal carcinoma cells.
TL;DR: Replication of human cytomegalovirus in human teratocarcinoma cells may depend on cellular functions associated with differentiation, as retinoic acid-induced differentiated derivatives of embryonal carcinoma cells were permissive for antigen expression and infectious virus production.
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Protective Effects of Towne Cytomegalovirus Vaccine Against Low-Passage Cytomegalovirus Administered as a Challenge
TL;DR: Vaccine-induced immunity to HCMV was as complete as naturally induced immunity when the challenge dose of Toledo was 10 pfu, and Volunteers who had been vaccinated 1 y earlier also were resistant to disease caused by 10 or 100 pfu of Toledo, although some were asymptomatically infected by the 100 p Fu dose.
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Cytotoxic T Lymphocyte (CTL) Responses to Human Cytomegalovirus pp65, IE1-Exon4, gB, pp150, and pp28 in Healthy Individuals: Reevaluation of Prevalence of IE1-Specific CTLs
Zsofia Gyulai,Valéria Endrész,Katalin Burián,Steve Pincus,Joseph Toldy,William I. Cox,Claude Meric,Stanley A. Plotkin,Eva Gonczol,Klara Berencsi +9 more
TL;DR: Moderately and highly seropositive donors showed predominantly pp65- and IE1-exon4-specific CTL responses, with similar precursor frequencies in the 2 donors tested, which may help to design a cellular immunity-based vaccine effective against HCMV diseases.