Eva-Maria Tanzer

Researcher at École Polytechnique Fédérale de Lausanne

Publications - 6

Citations - 179

Eva-Maria Tanzer is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Conformational isomerism & Pyrrolidine. The author has an hindex of 4, co-authored 5 publications receiving 163 citations. Previous affiliations of Eva-Maria Tanzer include University of Münster & ETH Zurich.

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Journal ArticleDOI

Fluorinated organocatalysts for the enantioselective epoxidation of enals: molecular preorganisation by the fluorine-iminium ion gauche effect.

Eva-Maria Tanzer, +3 more

- 03 Sep 2012 -

Chemistry: A European Journal

TL;DR: The fluorine-iminium ion gauche effect is triggered upon union of a secondary β-fluoroamine and an α,β-unsaturated aldehyde, providing a useful strategy for controlling the molecular topology of intermediates that are central to organocatalytic processes.

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Journal ArticleDOI

Designing Fluorinated Cinchona Alkaloids for Enantioselective Catalysis: Controlling Internal Rotation by a Fluorine‐Ammonium Ion gauche Effect (φNCCF)

Eva-Maria Tanzer, +3 more

- 13 Feb 2012 -

Chemistry: A European Journal

TL;DR: A fluoride-ammonium ion gauche effect constitutes a partial solution to the long-standing problem of governing internal rotations in cinchonium-based catalysts relying solely on a fluorine conformational effect.

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Journal ArticleDOI

Molecular Design Exploiting a Fluorine gauche Effect as a Stereoelectronic Trigger

Yannick P. Rey, +9 more

- 01 Feb 2014 -

European Journal of Organic Chemistry

TL;DR: This paper describes the application of a fluorine gauche effect to predictably control torsional rotation in a class of fluorinated 4-(dimethylamino)pyridine (DMAP) analogues and validate this design approach to control molecular space.

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Journal ArticleDOI

A Concise Synthesis of (S)-2-(Fluorodiphenylmethyl)pyrrolidine: ANovel Organocatalyst for the Stereoselective Epoxidation of α,β-UnsaturatedAldehydes

Christof Sparr, +3 more

- 01 Apr 2010 -

Synthesis

TL;DR: In this paper, a concise synthesis of (S)-2-(fluorodiphenylmethyl)pyrrolidine from cheap, commercially available starting materials is described, which includes ease of synthesis, computationally efficient purification steps, and an operationally simple deoxy-fluorination step to install the C-F bond.

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Eva-Maria Tanzer

Papers

Fluorinated organocatalysts for the enantioselective epoxidation of enals: molecular preorganisation by the fluorine-iminium ion gauche effect.

Designing Fluorinated Cinchona Alkaloids for Enantioselective Catalysis: Controlling Internal Rotation by a Fluorine‐Ammonium Ion gauche Effect (φNCCF)

Molecular Design Exploiting a Fluorine gauche Effect as a Stereoelectronic Trigger

A Concise Synthesis of (S)-2-(Fluorodiphenylmethyl)pyrrolidine: ANovel Organocatalyst for the Stereoselective Epoxidation of α,β-UnsaturatedAldehydes

Discovery of HPK1 Inhibitors with High Cellular Potency