Evgenij Fiskin

TL;DR: It is proposed that UBD-based biosensors could serve as prototypes to track and trace other chain types and ubiquitin-like signals in vivo.

TL;DR: The roles played by different classes of bacterial Ub ligases in infection and pathogenicity are described and an overview of the different mechanisms by which bacteria mimic specific components of the host Ub system is provided.

TL;DR: Dynamic changes in the global ubiquitinome of host epithelial cells and invading pathogen in response to Salmonella Typhimurium infection are reported and it is revealed that bacterial Ub-modifying enzymes modulate a unique subset of host targets, affecting different stages ofSalmonella infection.

TL;DR: The NMR and crystal structures of the autophagy modifier LC3B in complex with the LC3 interaction region of optineurin either phosphorylated or bearing phospho-mimicking mutations show that the negative charge induced by phosphorylation is recognized by the side chains of Arg¹¹ and Lys⁵¹ inLC3B.

TL;DR: It is demonstrated that SopA ubiquitinates TRIM56 and TRIM65, resulting in their proteasomal degradation during infection, and provides the basis for how a bacterial HECT ligase blocks host RING ligases and exemplifies the multivalent power of bacterial effectors during infection.