Ewart Thomas Cole

TL;DR: Filling and sealing technologies for hard capsules, provides the formulator with the flexibility of developing formulations in-house from small scale, as required for Phase I studies, up to production.

TL;DR: The product visualisation technique of gamma scintigraphy was used to establish the in vivo disintegration properties of HPMC units coated with Eudragit L 30 D-55, and complete disintegration occurred predominately in the small bowel in an average time of 2.4 h post dose.

TL;DR: In this paper, hot-melt screw extrusion was presented as an alternative method for producing polymer-based sustained release (SFL) pellets, which were produced with diltiazem hydrochloride as model drug.

TL;DR: In this paper, the authors used a double exponential decay equation to discriminate between surface release and diffusion-controlled release phases for diltiazem hydrochloride, and then optimized the release profile of the drug to achieve therapeutic plasma levels with a once or twice daily administration.

TL;DR: It was showed that it was not possible to increase the bioavailability of a poorly absorbed drug such as atenolol using gastroretentive formulations and the maximum plasma concentration was diminished.