Journal ArticleDOI
Various ways of modulating the release of diltiazem hydrochloride from hot-melt extruded sustained release pellets prepared using polymeric materials
TLDR
In this paper, the authors used a double exponential decay equation to discriminate between surface release and diffusion-controlled release phases for diltiazem hydrochloride, and then optimized the release profile of the drug to achieve therapeutic plasma levels with a once or twice daily administration.About:
This article is published in Journal of Controlled Release.The article was published on 1995-10-01. It has received 167 citations till now. The article focuses on the topics: Diltiazem hydrochloride & Pellets.read more
Citations
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Journal ArticleDOI
Melt extrusion: from process to drug delivery technology
TL;DR: Improved bioavailability was achieved again demonstrating the value of the technology as a drug delivery tool, with particular advantages over solvent processes like co-precipitation.
Journal ArticleDOI
Pharmaceutical Applications of Hot-Melt Extrusion: Part I
Michael M. Crowley,Feng Zhang,Michael A. Repka,Sridhar Thumma,Sampada B. Upadhye,Sunil Kumar Battu,James W. McGinity,Charles R. Martin +7 more
TL;DR: The pharmaceutical applications of hot-melt extrusion, including equipment, principles of operation, and process technology, are reviewed and the physicochemical properties of the resultant dosage forms are described.
Journal ArticleDOI
Hot-Melt Extrusion: from Theory to Application in Pharmaceutical Formulation
TL;DR: This review discussed the importance of using the quality by design approach in drug development, evaluated the process analytical technology used in pharmaceutical HME monitoring and control, discussed techniques used in HME, and emphasized the potential for monitoring and controlling hot-melt technology.
Patent
Melt-extruded orally administrable opioid formulations
TL;DR: In this paper, a plurality of multiparticulates produced via melt extrusion techniques are disclosed, which are used to produce bioavailable sustained release oral opioid analgesic dosage forms.
Journal ArticleDOI
Physicochemical properties and mechanism of drug release from ethyl cellulose matrix tablets prepared by direct compression and hot-melt extrusion.
Michael M. Crowley,Britta Schroeder,Anke Fredersdorf,Sakae Obara,Mark Talarico,Shawn A. Kucera,James W. McGinity +6 more
TL;DR: The Higuchi diffusion model, Percolation Theory and Polymer Free Volume Theory were applied to the dissolution data to explain the release properties of drug from the matrix systems and the release rate was shown to be dependent on the ethyl cellulose particle size, compaction force and extrusion temperature.
References
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Journal ArticleDOI
Evaluation of hot-melt extrusion as a new technique for the production of polymer-based pellets for sustained release capsules containing high loadings of freely soluble drugs
TL;DR: In this paper, hot-melt screw extrusion was presented as an alternative method for producing polymer-based sustained release (SFL) pellets, which were produced with diltiazem hydrochloride as model drug.
Journal Article
Matrix type controlled release systems: I. Effect of percolation on drug dissolution kinetics.
J.D. Bonny,Hans Leuenberger +1 more
TL;DR: In this paper, a matrix type controlled release tablet was prepared by compression of binary mixtures of a soluble brittle model drug (caffeine) and a plastic matrix substance (ethyl cellulose).
Journal ArticleDOI
Physical and Chemical Factors Influencing the Release of Drugs from Acrylic Resin Films
TL;DR: The rate of drug release increased with increasing temperature and adsorption of salicylic acid by the polymers was believed to influence the drug release profiles observed for different drug loadings and ionic strengths.
Journal ArticleDOI
A Comparative Evaluation of the Properties of some Tablet Disintegrants
D. Gissinger,A. Stamm +1 more
TL;DR: In this article, a cooperative evaluation of the properties of different disintegrants: starches (corn, maize, potatoe, rice) and derivatives (STARX 1500, carboxymethylstarches as PRIMOJEL or EXPLOTAB), celluloses (AVICEL, ELCEMA), macromolecules (Alginic acid, AMBERLITE IRP 88, ESMA SPRENG, Pectins, a.s.o.
Journal ArticleDOI
Mechanistic studies of macromolecular drug release from macroporous polymers. II. Models for the slow kinetics of drug release
Ronald A. Siegel,Robert Langer +1 more
TL;DR: The release of protein drugs such as bovine serum albumin from poly mers such as macroporous poly(ethylene-co-vinyl acetate) (EVAc) matrices has been shown previously to be much slower than would be predicted from simple considerations of aqueous diffusion.
Related Papers (5)
Properties of Sustained-Release Tablets Prepared by Hot-Melt Extrusion
Feng Zhang,James W. McGinity +1 more