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Ezequiel Neimark
Researcher at AbbVie
Publications - 45
Citations - 1348
Ezequiel Neimark is an academic researcher from AbbVie. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 9, co-authored 18 publications receiving 1020 citations. Previous affiliations of Ezequiel Neimark include Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Effect of tight control management on Crohn's disease (CALM): a multicentre, randomised, controlled phase 3 trial
Jean-Frederic Colombel,Remo Panaccione,Peter Bossuyt,Milan Lukas,Filip Baert,Tomáš Vaňásek,Ahmet Danalioglu,Gottfried Novacek,Alessandro Armuzzi,Xavier Hébuterne,Simon Travis,Silvio Danese,Walter Reinisch,William J. Sandborn,Paul Rutgeerts,Daniel W. Hommes,Stefan Schreiber,Ezequiel Neimark,Bidan Huang,Qian Zhou,Paloma Mendez,J Petersson,Kori Wallace,Anne M. Robinson,Roopal Thakkar,Geert R. D'Haens +25 more
TL;DR: This trial aimed to compare endoscopic and clinical outcomes in patients with moderate to severe Crohn's disease who were managed with a tight control algorithm, using clinical symptoms and biomarkers, versus patients management with a clinical management algorithm.
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Bile acid-induced negative feedback regulation of the human ileal bile acid transporter.
TL;DR: The human ASBT is positively regulated by retinoic acid via an FXR‐mediated, SHP‐dependent effect upon RAR/RXR activation of ASBT.
Journal ArticleDOI
Progressive familial intrahepatic cholestasis, type 1, is associated with decreased farnesoid X receptor activity☆
Frank Chen,Meenakshisundaram Ananthanarayanan,Sukru Emre,Ezequiel Neimark,Laura N. Bull,A. S. Knisely,Sandra Strautnieks,Richard J. Thompson,Margret S. Magid,Ronald E. Gordon,Natarajan Balasubramanian,Frederick J. Suchy,Benjamin L. Shneider +12 more
TL;DR: Loss of familial intrahepatic cholestasis-1 leads to diminished nuclear translocation of the FXR, with the subsequent potential for pathologic alterations in intestinal and hepatic bile acid transporter expression.
Journal ArticleDOI
Bile acid induced negative feedback regulation of the human ileal bile acid transporter is mediated by the farnesoid X-receptor (FXR), the short heterodimer partner (SHP), and the retinoid X receptor (RAR/RXR)
TL;DR: The human ASBT is positively regulated by retinoic acid via an FXR-mediated, SHP-dependent effect upon RAR/RXR activation of ASBT.
Journal ArticleDOI
Critical analysis of the pediatric end-stage liver disease scoring system: A single center experience
Benjamin L. Shneider,Ezequiel Neimark,Tamara Frankenberg,Lindsay Arnott,Frederick J. Suchy,Sukru Emre +5 more
TL;DR: The United Network for Organ Sharing policy that permits granting of exceptions has circumvented these problems with the PELD scoring system, and it appears that this scoring system underestimates the near‐term risk of death.