F Di Padova

TL;DR: The biological analysis of synthetic lipid A partial structures proved that the expression of endotoxic activity depends on a unique primary structure and a peculiar endotoxic conformation, and molecular and submolecular details of the specificity of the interaction of lipid A with responsive host cells are determined.

TL;DR: Endotoxins, due to their various potent biological activities soon attracted worldwide scientific interest, were first found to be produced by Vibrio cholerae bacteria and later by Salmonella and Serratia.

TL;DR: Evidence is provided that distinct extracellular signals leading to upregulation of MMP-1 expression in fibroblasts are relayed independently through different MAP kinase pathways and are integrated at the level of the promoter.

TL;DR: Pre-clinical observations suggest efficacy of AIN457 in myeloma and provide the rationale for its clinical evaluation for anti-myeloma effects and for improvement of bone disease.

TL;DR: Simultaneous activation of the p38s suggests that all four may be important in inflammation, and makes monoclonal antibodies specific for each p38 suggesting a common upstream activation pathway.