F M Abou-Tarboush

TL;DR: In this article, the authors used aqueous leaf extract of A. obesum (AOAgNPs) for the synthesis of silver nanoparticles, which were further characterized by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD) and transmission electron microscopy (TEM).

TL;DR: Results clearly show that ethanolic extract of L. dentata exhibits promising cytotoxic activity with an IC50 value of 39 μg/mL, and call for further investigations to determine the active chemical constituent(s) and their mechanisms of inducing apoptosis.

TL;DR: Molecular-docking analyses revealed that proceraside A was the best docked ligand against all the targets, with the exception of telomere-G: quadruplex, and critical hydrogen bonds and hydrophobic interactions with the targets were revealed.

TL;DR: The present computational approach may aid in rational identification of targets for small molecules against large set of candidate macromolecules before bioassays validation.

TL;DR: It is suggested that AOAgNPs increased the level of ROS resulting in heightened the DNA damage, apoptosis and autophagy in MCF-7 breast cancer cells.