F
Fabienne Bardou
Researcher at University of Toulouse
Publications - 18
Citations - 1739
Fabienne Bardou is an academic researcher from University of Toulouse. The author has contributed to research in topics: Mycolic acid & Mycobacterium tuberculosis. The author has an hindex of 14, co-authored 18 publications receiving 1576 citations. Previous affiliations of Fabienne Bardou include Centre national de la recherche scientifique & Paul Sabatier University.
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Journal ArticleDOI
Foamy Macrophages from Tuberculous Patients' Granulomas Constitute a Nutrient-Rich Reservoir for M. tuberculosis Persistence
Pascale Peyron,Julien Vaubourgeix,Julien Vaubourgeix,Yannick Poquet,Yannick Poquet,Florence Levillain,Florence Levillain,Catherine Botanch,Catherine Botanch,Fabienne Bardou,Fabienne Bardou,Mamadou Daffé,Mamadou Daffé,Jean-François Emile,Bruno Marchou,Pere-Joan Cardona,Chantal de Chastellier,Chantal de Chastellier,Chantal de Chastellier,Frederic Altare,Frederic Altare +20 more
TL;DR: Results suggest that oxygenated mycolic acids from M. tuberculosis play a crucial role in the differentiation of macrophages into FMs, a granuloma-specific cell population characterized by its high lipid content, and could provide a relevant model for the screening of new antimicrobials against non-replicating persistent mycobacteria.
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Identification of the surface-exposed lipids on the cell envelopes of Mycobacterium tuberculosis and other mycobacterial species.
A. Ortalo-Magne,Anne Lemassu,Marie-Antoinette Lanéelle,Fabienne Bardou,Gaby Silve,P. Gounon,G. Marchal,Mamadou Daffé +7 more
TL;DR: Analysis of the exposed lipids demonstrated a selective location of classes of ubiquitous lipids on the surfaces of mycobacteria, leading to the proposal of a scheme for the location of the capsular lipids of the tubercle bacillus.
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The Acyl-AMP Ligase FadD32 and AccD4-containing Acyl-CoA Carboxylase Are Required for the Synthesis of Mycolic Acids and Essential for Mycobacterial Growth IDENTIFICATION OF THE CARBOXYLATION PRODUCT AND DETERMINATION OF THE ACYL-CoA CARBOXYLASE COMPONENTS
Damien Portevin,Célia de Sousa-d'Auria,Henri Montrozier,Christine Houssin,Alexandre Stella,Marie-Antoinette Lanéelle,Fabienne Bardou,Christophe Guilhot,Mamadou Daffé +8 more
TL;DR: Comp comparative genomics and applied a combination of molecular biology and proteomic technologies to the analysis of proteins that co-immunoprecipitated with AccD4 resulted in the identification of AccA3 and AccD5 as subunits of the acyl-CoA carboxylase.
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The Pks13/FadD32 crosstalk for the biosynthesis of mycolic acids in Mycobacterium tuberculosis.
Sabine Gavalda,Sabine Gavalda,Mathieu Léger,Mathieu Léger,Benoît van der Rest,Benoît van der Rest,Alexandre Stella,Fabienne Bardou,Fabienne Bardou,Henri Montrozier,Henri Montrozier,Christian Chalut,Christian Chalut,Odile Burlet-Schiltz,Hedia Marrakchi,Hedia Marrakchi,Mamadou Daffé,Mamadou Daffé,Annaïk Quémard,Annaïk Quémard +19 more
TL;DR: An active form of the Pks13 polyketide synthase is produced and purified, with a phosphopantetheinyl (P-pant) arm at both positions Ser-55 and Ser-1266 of its two acyl carrier protein (ACP) domains, and will constitute a strategic tool for antimycobacterial drug screening.
Journal ArticleDOI
Mechanism of isoniazid uptake in Mycobacterium tuberculosis
TL;DR: It is proposed that INH transport occurs by passive diffusion, and that catalase-peroxidase (KatG) is not involved in the actual transport, because conditions inhibiting KatG activity decrease cell radioactivity at the uptake plateau.