F
Fabio Broccatelli
Researcher at Genentech
Publications - 29
Citations - 1488
Fabio Broccatelli is an academic researcher from Genentech. The author has contributed to research in topics: Medicine & Pharmacokinetics. The author has an hindex of 15, co-authored 25 publications receiving 1212 citations. Previous affiliations of Fabio Broccatelli include University of California, San Francisco & Institute of Cancer Research.
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Journal ArticleDOI
BDDCS Applied to Over 900 Drugs
TL;DR: The potential use of BDDCS to estimate the disposition characteristics of novel chemicals (new molecular entities) in the early stages of drug discovery and development and the influence of several measured and in silico parameters in the process of B DDCS category assignment is discussed in detail.
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A Novel Approach for Predicting P-glycoprotein (ABCB1) Inhibition Using Molecular Interaction Fields
Fabio Broccatelli,Emanuele Carosati,Annalisa Neri,Maria Frosini,Laura Goracci,Tudor I. Oprea,Gabriele Cruciani +6 more
TL;DR: A model was constructed using various molecular interaction field-based technologies, considering pharmacophoric features and those physicochemical properties related to membrane partitioning that confirmed the robustness of the model and its suitability to help medicinal chemists in drug discovery.
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1,4-Dihydropyridine Scaffold in Medicinal Chemistry, The Story So Far And Perspectives (Part 2): Action in Other Targets and Antitargets
Emanuele Carosati,Pierfranco Ioan,Matteo Micucci,Fabio Broccatelli,Gabriele Cruciani,Bs Zhorov,Alberto Chiarini,Roberta Budriesi +7 more
TL;DR: Ioan et al. as mentioned in this paper analyzed the effects of 1,4-Dihydropyridines at ion channels and G-protein coupled receptors. And they reported the interaction of 1 4-DHP with the hERG channel, transporters and phase I metabolizing enzymes.
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In Silico Absorption, Distribution, Metabolism, Excretion, and Pharmacokinetics (ADME-PK): Utility and Best Practices. An Industry Perspective from the International Consortium for Innovation through Quality in Pharmaceutical Development
Franco Lombardo,Prashant V. Desai,Rieko Arimoto,Kelly E. Desino,Holger Fischer,Christopher Keefer,Carl Petersson,Susanne Winiwarter,Fabio Broccatelli +8 more
TL;DR: An overview on the benefits, caveats, and impact of in silico ADME-PK should serve as a resource for medicinal Chemists, computational chemists, and DMPK scientists working in drug design to increase their knowledge in the area.
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1,4-Dihydropyridine scaffold in medicinal chemistry, the story so far and perspectives (part 1): action in ion channels and GPCRs.
Pierfranco Ioan,Emanuele Carosati,Matteo Micucci,Gabriele Cruciani,Fabio Broccatelli,Boris S. Zhorov,Alberto Chiarini,Roberta Budriesi +7 more
TL;DR: The structure-activity relationships of 1,4-DHPs at ion channels, G-protein coupled receptors, and the potential for future therapeutic applications are described and outlined.