Fabrício A. Pamplona

TL;DR: CBD, a non-psychoactive phytocannabinoid could be an interesting pharmacological approach to reduce the anxiogenic effects of stress and promote the extinction of fear memories.

TL;DR: These results suggest cannabinoid receptor agonists as potential drugs to treat anxiety disorders related to the retrieval of aversive memoriesrelated to the extinction of contextual fear memory.

TL;DR: The present data suggest that caffeine and selective adenosine A2A receptor antagonists can improve memory performance in rodents evaluated through different tasks and afford protection against memory dysfunction elicited in experimental models of aging, Alzheimer's disease, Parkinson's disease and, in spontaneously hypertensive rats (SHR), a putative genetic model of attention deficit hyperactivity disorder (ADHD).

TL;DR: It is shown that the anti-inflammatory lipid lipoxin A4 is an endogenous allosteric enhancer of the CB1 cannabinoid receptor, and displayed a CB1 receptor-dependent protective effect against β-amyloid (1–40)-induced spatial memory impairment in mice.

TL;DR: The present findings highlight that cannabinoid agonists effects are selective for the hippocampus-dependent aversive memories in rats and confirms that cannabinoids might provide a novel approach for the treatment of unpleasant memories.