F
Fabrizio Costantini
Researcher at University of Chieti-Pescara
Publications - 27
Citations - 2405
Fabrizio Costantini is an academic researcher from University of Chieti-Pescara. The author has contributed to research in topics: Vitamin E & Blood pressure. The author has an hindex of 19, co-authored 27 publications receiving 2341 citations. Previous affiliations of Fabrizio Costantini include University of Ferrara.
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Journal ArticleDOI
In Vivo Formation of 8-Iso-Prostaglandin F2α and Platelet Activation in Diabetes Mellitus
Giovanni Davì,Giovanni Ciabattoni,Agostino Consoli,Andrea Mezzetti,Antonio Falco,Stella Santarone,Elsa Pennese,Ester Vitacolonna,Tonino Bucciarelli,Fabrizio Costantini,Fabio Capani,Carlo Patrono +11 more
TL;DR: Vitamin E supplementation, metabolic control, and cyclooxygenase inhibitors were used to investigate the mechanisms of formation of the F2-isoprostane 8-iso-PGF2α in this setting.
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In Vivo Formation of 8-Epi-Prostaglandin F2α Is Increased in Hypercholesterolemia
Giovanni Davì,Paola Alessandrini,Andrea Mezzetti,Giorgio Minotti,Tonino Bucciarelli,Fabrizio Costantini,Francesco Cipollone,Gabriele Bittolo Bon,Giovanni Ciabattoni,Carlo Patrono +9 more
TL;DR: It is concluded that the in vivo formation of the F2-isoprostane 8-epi-PGF2α is enhanced in the vast majority of patients with hypercholesterolemia and dose-dependent suppression of enhanced 8-Epi- PGF2 α formation by vitamin E supplementation may contribute to the beneficial effects of antioxidant treatment.
Journal ArticleDOI
Vitamins E, C and lipid peroxidation in plasma and arterial tissue of smokers and non-smokers.
Andrea Mezzetti,Domenico Lapenna,Sante D. Pierdomenico,Antonio M. Calafiore,Fabrizio Costantini,Giuseppe Riario-Sforza,T. Imbastaro,Matteo Neri,Franco Cuccurullo +8 more
TL;DR: In this paper, the arterial (internal mammary artery) and plasma levels of vitamins E and C and lipid peroxides in 48 male patients, 24 smokers and 24 non-smokers, undergoing coronary bypass surgery were assessed.
Journal ArticleDOI
Increased circulating nitric oxide in young patients with type 1 diabetes and persistent microalbuminuria: relation to glomerular hyperfiltration.
F. Chiarelli,Francesco Cipollone,Ferdinando Romano,Stefano Tumini,Fabrizio Costantini,L. di Ricco,M Pomilio,Sante D. Pierdomenico,Matteo Marini,Franco Cuccurullo,Andrea Mezzetti +10 more
TL;DR: It is suggested that in young type 1 diabetic patients with early nephropathy, chronic hyperglycemia is associated with an increased NO biosynthesis and action that contributes to generating glomerular hyperfiltration and persistent microalbuminuria.
Journal ArticleDOI
Copper/zinc ratio and systemic oxidant load: effect of aging and aging-related degenerative diseases
Andrea Mezzetti,Sante D. Pierdomenico,Fabrizio Costantini,Ferdinando Romano,Domenico De Cesare,Franco Cuccurullo,T. Imbastaro,Giuseppe Riario-Sforza,Franco Di Giacomo,Giovanni Zuliani,Renato Fellin +10 more
TL;DR: There is a strict relationship between copper/zinc ratio and systemic oxidant burden and advanced age and, particularly, advanced age-related chronic degenerative diseases are associated with a significant increase in the copper/Zinc ratios and systemic oxidative stress.