Showing papers in "Atherosclerosis in 1995"

TL;DR: The data suggest that natural antioxidants could play a role in inhibiting the formation of cytotoxic products such as lipid peroxides thus retarding the onset of the atherosclerotic damage.

TL;DR: Evidence that some of these might act to metabolise lipid peroxidation products, such as oxidised phospholipids and lyso-phosphatidylcholine, is discussed in this review.

TL;DR: It is concluded that the systemic synthesis of NO is impaired in cholesterol-fed rabbits, as indicated by the decreased urinary excretion of NO3-.

TL;DR: It is concluded that death of macrophage foam cells contributes to the origin and slow enlargement of the lipid core.

TL;DR: Results suggest that platelet-derived microparticles may participate in the development or progression of atherosclerosis in patients with diabetes mellitus.

TL;DR: The data suggest that loss of the sizable homocysteine metabolizing capacity of the intact kidneys may be an important determinant of the refractory, potentially atherothrombotic hyperhomocysteinemia frequently observed in ESRD.

TL;DR: In this paper, the arterial (internal mammary artery) and plasma levels of vitamins E and C and lipid peroxides in 48 male patients, 24 smokers and 24 non-smokers, undergoing coronary bypass surgery were assessed.

TL;DR: It is suggested that IL-1 beta is a potent inducer for ICAM-1 and VCAM- 1 expression in human vascular SMC, and could play a role in the pathogenesis of atherosclerosis by recruitment and retention of inflammatory cells such as monocytes and neutrophils in the lesions.

TL;DR: Oral serine supplementation caused a 37% increase in mean plasma serine, but had no effect on plasma homocysteine in four ESRD patients with supernormal plasma folate, low plasma Serine, and hyperhomocysteinemia.

TL;DR: High density lipoprotein lipid fractions were determined and correlated with the release of ROS by leukocytes monitored by luminol-enhanced chemiluminescence, and HLP showed the highest ROS production by resting mononuclear leukocyte among the three study groups.

TL;DR: It is concluded that fasting total plasma homocysteine determination alone fails to identify a sizable percentage of persons who may have clinically relevant hyperhomocysteinemia post methionine loading.

TL;DR: A meta-analysis utilizing published data from 4 previously published studies as well as the own data with a total sample size of 625 subjects indicates that the presence of the APOE*2 allele was associated with a significantly greater LDL-cholesterol lowering response than those subjects homozygous for the APoe*3 allele at 35%, while those with theAPOE*4 allele had a significantly lower response.

TL;DR: Poly(organo)phosphazene induced a more pronounced histiolymphocytic and fibromuscular reaction than amphiphilic polyurethane, which appeared to be promising as biocompatible stent coating and, consequently, as a potential carrier for vasoactive drugs.

TL;DR: It is concluded that AN-II stimulates macrophage-mediated mediated oxidation of LDL secondary to cellular lipid peroxidation, and this may have a role in the accelerated atherosclerosis found in hypertensive patients.

TL;DR: A novel hypocholesterolemic agent is described and its pharmacological effects in animal models of hypercholesterolemia are documented and it is shown that 1 mg/kg SCH 48461 rapidly reversed the elevated VLDL + LDL-cholesterol levels of the previous control group to near baseline values.

TL;DR: It is concluded that cigarette smoking is associated with increased fibrinogen levels, unaltered fibrinolysis, normal glucose tolerance and insulin levels, and the use of smokeless tobacco, as moist oral snuff, does not appear to affect these potential cardiovascular risk factors.

TL;DR: Endothelin-1, thromboxane A2 and prostaglandin H2 are endothelium-derived contracting factors which have no direct platelet effects, but has proliferative properties in vascular smooth muscle and Nitric oxide, prostacyclin and a putative hyperpolarizing factor mediate relaxation.

TL;DR: The cytotoxic potency of 26-hydroxycholesterol was the greatest and the 7-position derivatives also produced marked cell damage, though at higher concentrations than for 26-Hydroxych cholesterol, of the oxysterols assessed.

TL;DR: There was no demonstrable effect of garlic on oxidisability of LDL, on the ratio of plasma lathosterol/cholesterol (a measure of cholesterol synthesis), nor on LDL receptor expression in lymphocytes in subjects with mild to moderate hypercholesterolaemia.

TL;DR: The results support previous studies in suggesting that the apo E allele epsilon 4 is a risk factor for atherosclerosis, which affects plasma total and LDL-cholesterol and suggest that the APO E allele determines the severity of CAD.

TL;DR: The pharmacologic strategies including the stimulation of generation of endogenous NO, NO-replacement therapy and decreasing oxidative stress may be useful for ameliorating the clinical course of atherosclerosis.

TL;DR: Apolipoprotein E is a secretory glycoprotein that associates with lipoprotein particles and is coded for by a single locus on chromosome 19, and the presence of the apo E4 isoform constitutes a major risk for developing late-onset Alzheimer's disease as well as hypercholesterolaemia.

TL;DR: The associations previously found between lipoprotein(a) (Lp(a)) levels and atherosclerotic disorders, diabetes, rheumatoid arthritis and renal diseases suggest that Lp (a) may be involved in autoimmune reactions, and the relation found between Lp( a) levels and the HLA class II genotype in males with early coronary artery disease (CAD) further support that assumption.

TL;DR: The results of this study suggest that group II PLA2 may actively be involved in the formation of foam cells in vivo in view of the fact that the in vitro modification of lipoproteins by PLA2-treatment induces lipid deposition in macrophages.

TL;DR: In this study, the concentration of plasma homocyst(e)ine in men who lacked a history of atherosclerotic disease was correlated with hemodynamic, rheological and biochemical parameters, and multivariate analyses demonstrated that systolic blood pressure, plasma uric acid, and hematocrit were predictors of concentrations of plasma HomocySt(e), after adjusting for certain risk factors.

TL;DR: It is concluded that menopause is associated with the aggravation of multiple cardiovascular risk factors and these deleterious factors are affected by a treatment of combining estrogen and progestin.

TL;DR: In vivo β-carotene supplementation may lead to a shortening of the lag phase of Cu 2+ -induced lipid peroxidation in LDL, indicating that the protection of LDL against metal ion-dependent and -independent oxidation is not enhanced.

TL;DR: Multivariate analysis showed that TG, HDL content and HL activity were the most important determinants of small dense LDL concentration in the fasting state and postprandially, chylomicron remnant clearance, HL and insulin resistance were the major determinant of LDL-III.

TL;DR: It is confirmed that high-methionine diet may induce atherosclerosis in rabbits and indicate disturbances in lipid peroxidation and antioxidant processes as possible mechanisms of its atherogenic influence.